Table 4 Time evolution of lactate concentrations and hepatic lactate exchange

Arterial lactate (mmol/l)

Control

6

0.67 (0.3–0.7)

0.92 (0.6–1.1)

0.028

NE

7

0.66 (0.4–0.8)

1.1 (0.7–2.1)

0.028

Hepatic vein lactate (mmol/l)

Control

6

0.45 (0.4–0.6)

0.71 (0.5–1.1)

0.028

NE

6

0.41 (0.3–0.5)

0.89 (0.7–1.7)

0.028

Portal vein lactate (mmol/l)

Control

4

0.74 (0.6–0.9)

1 (0.6–1.23)

0.14

NE

7

0.68 (0.5–0.9)

1.1 (0.9–1.9)

0.028

Hepatic lactate influx (μmol/minute per kg)

Control

4

18.1 (15–21)

21.8 (15–24)

0.3

NE

6

18.3 (8–24)

38.5 (14–42)

0.028

Hepatic lactate uptake (μmol/minute per kg)

Control

4

7.4 (7–12)

4.1 (0.3–10)

0.07

NE

6

6.6 (4–11)

5.7 1.7–13)

0.6

Hepatic lactate extraction ratio (%)

Control

4

44 (38–60)

22 (2–41)

0.05

NE

6

40 (29–51)

17 (9–34)

0.046