Table 1 Artificial oxygen carriers
From: Bench-to-bedside review: Latest results in hemorrhagic shock
Category | Product | Type | MW (Daltons) | Phase of testing |
|---|---|---|---|---|
Perfluorocarbons | Oxygent™ | Perfluoroctylbromide | 450 to 500 | Up to clinical phase III, discontinued |
Hemoglobin-based oxygen carrier | HemAssist™ | Diaspirin-crosslinked hemoglobin (human) | 65,000 | Up to clinical phase III, discontinued |
Hemopure™ | Polymerized bovine hemoglobin (bovine) | 250,000 | Up to clinical phase III | |
Polyheme™ | Pyridoxylated glutaraldehyde-polymerized hemoglobin (human) | 150,000 | Up to clinical phase III | |
Hemospan™ | Maleimide-activated polyethylene-glycol-modified hemoglobin (human) | 95,000 | Up to clinical phase II, phase III planned | |
Hemoglobin vesicles | Oxygenix™ | Hemoglobin containing liposomes (OXY-0301) | Unpublished | Experimental, up to phase I |