Table 3 Characteristics of patients experiencing serious bleeding events
From: Drotrecogin alfa (activated): real-life use and outcomes for the UK
| Characteristics | Admissions experiencing serious bleeding events (n = 80) |
|---|---|
| Site of serious bleeding event (n [%]) | |
| Gastrointestinal | 29 (33.7) |
| Skin or soft tissue | 19 (22.1) |
| Intra-abdominal | 9 (10.5) |
| Intracranial | 7 (8.1) |
| Intrathoracic | 5 (5.8) |
| Genitourinary | 3 (3.5) |
| Retroperitoneal | 0 (0.0) |
| Other (source identified)a | 6 (7.0) |
| Other (source unidentified) | 5 (5.8) |
| Age (years; mean ± SD) | 58.5 (14.9) |
| APACHE II score (mean ± SD) | |
| Acute physiology score | 19.6 (7.5) |
| Score | 22.9 (7.6) |
| ICNARC model physiology score (mean ± SD) | 30.5 (8.3) |
| Serious conditions in past medical historyb (n [%]) | |
| Liver | 1 (1.3) |
| Cardiovascular | 0 (0.0) |
| Respiratory | 0 (0.0) |
| Renal | 1 (1.3) |
| Immunosuppressed | 4 (5.0) |
| Admission typec (n [%]) | |
| Medical | 55 (68.8) |
| Elective surgical | 3 (3.8) |
| Emergency surgical | 22 (27.5) |
| Organ systems failing during first 24 hours of stay in critical care (n [%]) | |
| Cardiovascular | 79 (98.8) |
| Respiratory | 72 (90.0) |
| Renal | 32 (40.5) |
| Haematological | 28 (35.0) |
| Metabolic acidosis | 68 (85.0) |
| Number of organ systems failing during first 24 hours of stay in critical care (n [%]) | |
| <2 | 1 (1.3) |
| 2 | 5 (6.3) |
| 3 | 38 (47.5) |
| 4 | 26 (32.5) |
| 5 | 10 (12.5) |
| Primary site of infectiond (n [%]) | |
| Lung | 20 (27.0) |
| Abdomen | 33 (44.6) |
| Urinary tract | 5 (6.8) |
| Other | 16 (21.6) |
| Positive blood culturee (n [%]) | 26 (36.1) |
| Organisms cultured (n [%]) | |
| Any | 52 (65.8) |
| Gram-negative | 22 (42.3) |
| Gram-positive | 26 (50.0) |
| Fungus | 12 (23.1) |
| Mortality (n [%]) | |
| Unit | 31 (3 8.8) |
| Hospitalf | 39 (48.8) |
| Location at 28 days (n [%]) | |
| Died | 30 (37.5) |
| Unit | 22 (27.5) |
| Hospital | 22 (27.5) |
| Out of Hospitalf | 6 (7.5) |
| Unit length of stay (days; median [IQR]) | |
| Unit survivors | 20.7 (12.7–28.5) |
| Unit non-survivors | 9.8 (5.9–23.9) |
| Hospitalg length of stay (days; median [IQR]) | |
| Hospital survivors | 60 (43–105) |
| Hospital nonsurvivors | 19 (8–32) |