Table 3 Characteristics of patients experiencing serious bleeding events
From: Drotrecogin alfa (activated): real-life use and outcomes for the UK
Characteristics | Admissions experiencing serious bleeding events (n = 80) |
|---|---|
Site of serious bleeding event (n [%]) | |
   Gastrointestinal | 29 (33.7) |
   Skin or soft tissue | 19 (22.1) |
   Intra-abdominal | 9 (10.5) |
   Intracranial | 7 (8.1) |
   Intrathoracic | 5 (5.8) |
   Genitourinary | 3 (3.5) |
   Retroperitoneal | 0 (0.0) |
   Other (source identified)a | 6 (7.0) |
   Other (source unidentified) | 5 (5.8) |
Age (years; mean ± SD) | 58.5 (14.9) |
APACHE II score (mean ± SD) | |
   Acute physiology score | 19.6 (7.5) |
   Score | 22.9 (7.6) |
ICNARC model physiology score (mean ± SD) | 30.5 (8.3) |
Serious conditions in past medical historyb (n [%]) | |
   Liver | 1 (1.3) |
   Cardiovascular | 0 (0.0) |
   Respiratory | 0 (0.0) |
   Renal | 1 (1.3) |
   Immunosuppressed | 4 (5.0) |
Admission typec (n [%]) | |
   Medical | 55 (68.8) |
   Elective surgical | 3 (3.8) |
   Emergency surgical | 22 (27.5) |
Organ systems failing during first 24 hours of stay in critical care (n [%]) | |
   Cardiovascular | 79 (98.8) |
   Respiratory | 72 (90.0) |
   Renal | 32 (40.5) |
   Haematological | 28 (35.0) |
   Metabolic acidosis | 68 (85.0) |
Number of organ systems failing during first 24 hours of stay in critical care (n [%]) | |
   <2 | 1 (1.3) |
   2 | 5 (6.3) |
   3 | 38 (47.5) |
   4 | 26 (32.5) |
   5 | 10 (12.5) |
Primary site of infectiond (n [%]) | |
   Lung | 20 (27.0) |
   Abdomen | 33 (44.6) |
   Urinary tract | 5 (6.8) |
   Other | 16 (21.6) |
Positive blood culturee (n [%]) | 26 (36.1) |
Organisms cultured (n [%]) | |
   Any | 52 (65.8) |
   Gram-negative | 22 (42.3) |
   Gram-positive | 26 (50.0) |
   Fungus | 12 (23.1) |
Mortality (n [%]) | |
   Unit | 31 (3 8.8) |
   Hospitalf | 39 (48.8) |
Location at 28 days (n [%]) | |
   Died | 30 (37.5) |
   Unit | 22 (27.5) |
   Hospital | 22 (27.5) |
   Out of Hospitalf | 6 (7.5) |
Unit length of stay (days; median [IQR]) | |
   Unit survivors | 20.7 (12.7–28.5) |
   Unit non-survivors | 9.8 (5.9–23.9) |
Hospitalg length of stay (days; median [IQR]) | |
   Hospital survivors | 60 (43–105) |
   Hospital nonsurvivors | 19 (8–32) |