Table 2 Summary of acute physiology and laboratory parameters by sepsis and AKI
From: Early acute kidney injury and sepsis: a multicentre evaluation
| Â | None (n = 57,392) | Sepsis, no AKI (n = 19,336) | Nonseptic AKI (n = 29,356) | Septic AKI (n = 14,039) | P |
|---|---|---|---|---|---|
APACHE II score (mean [SD]) | 14.4 (6.4) | 15.4 (7.0) | 20.0 (7.9) | 22.3 (8.1) | <0.0001 |
GCS score (median [IQR]) | 15 (14–15) | 15 (13–15) | 15 (13–15) | 15 (12–15) | 0.001 |
Mean arterial pressure (mmHg; mean [SD]) | 84.3 (26.9) | 86.5 (27.7) | 81.3 (28.2) | 77.5 (28.3) | <0.0001 |
Heart rate (beats/minute; mean [SD]) | 91 (31) | 96 (32) | 96 (33) | 104 (35) | <0.0001 |
Respiratory rate (breaths/minute; mean [SD]) | 18 (10) | 20 (11) | 20 (10) | 23 (11) | <0.0001 |
PaO2/FiO2 ratio (mean [SD]) | 287 (154) | 262 (145) | 260 (153) | 230 (140) | <0.0001 |
PaCO2 (mmHg; mean [SD]) | 42.7 (12.4) | 42.5 (13.1) | 43.2 (14.5) | 42.0 (14.5) | <0.0001 |
Temperature (°C; mean [SD]) | 36.7 (1.5) | 36.8 (1.6) | 36.6 (1.6) | 36.9 (1.7) | <0.0001 |
Mechanical ventilation (%) | 53.3 | 49.5 | 52.6 | 49.2 | <0.0001 |
pH (mean [SD]) | 7.35 (0.1) | 7.35 (0.1) | 7.30 (0.1) | 7.29 (0.1) | <0.0001 |
Bilirubin (mmol/l; median [IQR]) | 12 (6–18) | 12 (6–18) | 13 (6–19) | 14 (7–21) | 0.0001 |
Albumin (g/l; mean [SD]) | 28.2 (7.4) | 27.8 (7.6) | 26.2 (7.6) | 25.1 (7.4) | <0.0001 |
Haematocrit (%; median [IQR]) | 0.33 (0.28–0.39) | 0.34 (0.28–0.39) | 0.31 (0.27–0.39) | 0.32 (0.27–0.38) | 0.0001 |
White cell count (× 109 cells/ml; mean [SD]) | 13.4 (9.7) | 14.2 (13.8) | 15.0 (11.5) | 16.8 (14.7) | <0.0001 |
Potassium (mmol/l; mean [SD]) | 4.2 (0.7) | 4.1 (0.7) | 4.5 (1.0) | 4.4 (1.0) | <0.0001 |
Creatinine (μmol/l; median [IQR]) | 76 (60–90) | 73 (57–90) | 141 (113–200) | 165 (124–254) | 0.0001 |
Urea (mmol/l; median [IQR]) | 5.3 (4–7) | 5.6 (4–7.8) | 10.4 (7.3–16.1) | 13.2 (8.9–19.8) | 0.0001 |
Urine output (l/24 hours; median [IQR]) | 2.12 (1.54–2.97) | 2.05 (1.50–2.98) | 1.40 (0.68–2.28) | 1.39 (0.66–2.30) | 0.0001 |