Table 1 PROWESS and ENHANCE patient baseline characteristics
Variable | PROWESS | ENHANCE | |
|---|---|---|---|
| Â | Placebo (n = 840) | DrotAA (n = 850) | DrotAA (n = 2378) |
Sex (% male [n]) | 58.0 (487) | 56.1 (477) | 58.2 (1383) |
Mean age (years [SD]) | 60.6 (16.5) | 60.5 (17.2) | 59.1 (16.9) |
Caucasian (% [n]) | 82.0 (689) | 81.8 (695) | 90.6 (2154) |
APACHE II score (mean [SD]) | 25.0 (7.8) | 24.6 (7.6) | 22.0 (7.4) |
SOFA score (mean [SD]) | Â | Â | Â |
   Cardiovascular | 2.7 (1.5) | 2.6 (1.5) | 3.0 (1.4) |
   Respiratory | 2.7 (1.1) | 2.7 (1.0) | 2.7 (1.0) |
   Renal | 1.1 (1.1) | 1.1 (1.1) | 1.3 (1.2) |
   Hematologic | 0.7 (1.0) | 0.7 (0.9) | 0.8 (1.0) |
   Hepatic | 0.6 (0.9) | 0.6 (0.8) | 0.7 (0.9) |
Protein C (median [IQR]) | 50 (33 to 68) | 47 (30 to 63) | 45 (30 to 64) |
Protein S (median [IQR]) | 38 (23 to 58) | 35 (33 to 57) | - |
Antithrombin III (median [IQR]) | 60 (45 to 75) | 58 (43 to 74) | - |
Interleukin-6 (median [IQR]) | 484 (129 to 2539) | 496 (153 to 2701) | - |
Prothrombin time (median [IQR]) | 18.6 (16.4 to 21.8) | 18.7 (16.6 to 22.1) | - |
D-dimer (median [IQR]) | 4.1 (2.2 to 8.7) | 4.2 (2.3 to 8.1) | - |