Intensive insulin therapy and mortality in critically ill patients

Table 5 Multivariable regression analysis: intensive care unit and hospital mortality in population subgroups^a

	Period I (n = 2,366) 1 Mar 01 to 28 Feb 02	Period II (n = 3,322) 1 Mar 02 to 30 Jun 03	Period III (n = 4,786) 1 Jul 03 to 28 Feb 05
	OR (95% CI)	OR (95% CI)	OR (95% CI)
Surgical and trauma ICU population
	n = 1,429	n = 1,991	n = 3,011
ICU mortality	1.00	1.27 (0.97, 1.67)	1.40 (1.08, 1.82)^b
Hospital mortality	1.00	1.18 (0.94, 1.48)	1.18 (0.95, 1.47)
Trauma ICU population^c
	n = 854	n = 1,195	n = 1,866
ICU mortality	1.00	1.25 (0.85, 1.84)	1.76 (1.23, 2.53)^d
Hospital mortality	1.00	1.12 (0.81, 1.54)	1.16 (0.85, 1.57)
Medical ICU population
	n = 920	n = 1,301	n = 1,641
ICU mortality	1.00	1.12 (0.83, 1.52)	1.10 (0.82, 1.47)
Hospital mortality	1.00	1.02 (0.87, 1.41)	1.11 (0.87, 1.41)

^aAll estimates are adjusted for admission age, history of diabetes, Simplified Acute Physiology Score (SAPS) II with age points removed, and mechanical ventilation at ICU admission. ^bP <0.05 multivariable regression (maximum likelihood estimation). ^cIn the trauma ICU population, the models also adjust for Injury Severity Score. ^dP <0.01 multivariable regression (maximum likelihood estimation). CI, confidence interval; ICU, intensive care unit; OR, odds ratio.

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