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Table 3 Complications

From: Early treatment of imported falciparum malaria in the intermediate and intensive care unit setting: an 8-year single-center retrospective study

Criteria Definition Number of patients (%)
Unrousable coma Glasgow Coma Scale score ≤9; exclude other causes; should persist ≥30 minutes after a generalized convulsion 3 (2,5)
Impaired consciousness Mental clouding, rousable 11 (9)
Multiple seizures Three or more convulsions observed within 24 hours 0 (0)
Respiratory distress Acidotic breathing, pulmonary oedema, or acute respiratory distress syndrome, on the basis of radiographic densities, hypoxaemia, and positive end-expiratory pressure 4 (3.3)
Circulatory collapse or shock Systolic blood pressure <80 mmHg despite adequate volume repletion 5 (4.1)
Abnormal bleeding Spontaneous bleeding from gums, nose, gastrointestinal tract, or laboratory evidence of disseminated intravascular coagulation 4 (3.3)
Jaundice/hyperbilirubinaemia Icteric sclera/buccal mucosa, or serum bilirubin >50 μmol/l (>3 mg/dl) 17 (13.9)
Severe anaemia Heemoglobin concentration <5 g/l, or haematocrit <15% 0 (0)
Hypoglycaemia Whole blood glucose concentration <2.2 mmol/l (<40 mg/dl) 3 (2.5)
Renal failure Serum creatinine >265 μmol/l, oliguria (<400 ml/24 hours) despite adequate rehydration 5 (4.1)
Hyperparasitaemia More than 5% parasitized erythrocytes or >250,000 parasites/μl (in nonimmune individuals) 13 (10.7)
Acidosis Plasma bicarbonate <15 mmol/l or base excess under -10, or acidaemia (arteria/capillaryl pH <7.25) 4 (3.3)
Macroscopic haemoglobinuria Dark or red urine; exclude haematuria, haemolysis not secondary to glucose-6-phosphate dehydrogenase deficiency ND
  1. The complications are defined according to the World Health Organization classification system [20] (n = 34 patients). ND, not determined