Effects of plasma expansion with albumin and paracentesis on haemodynamics and kidney function in critically ill cirrhotic patients with tense ascites and hepatorenal syndrome: a prospective uncontrolled trial

Table 3 Immediate effects of plasma expansion with 200 ml 20% human albumin solution (n = 19)

Parameter	Before plasma expansion	After plasma expansion	P
MAP (mmHg)	82 (69–92)	83 (70–89)	0.852
CVP (mmHg)	9 (7–12)	10 (7–13)	0.205
GEDVI (ml m^-2)	791 (693–862)	844 (751–933)	0.001
SVRI (dyn s cm^-5 m^-2)	1,422 (1,081–1,772)	1,171 (893–1,705)	0.006
CI (l min^-1 m^-2)	4.1 (3.6–5.0)	4.7 (4.0–5.8)	<0.001
CC (ml min^-1) over 12 h	23 (16–38)	23 (16–50)	0.227
FeNa (%) over 12 h	0.04 (0.02–0.05)	0.04 (0.03–0.06)	0.152

Data are presented as median (25th to 75th centile). MAP, mean arterial pressure; CVP, central venous pressure; GEDVI, global end-diastolic volume index; SVRI, systemic vascular resistance index; CI, cardiac index; CC, creatinine clearance; FeNa, fractional excretion of sodium.

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