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Clinical efficacy of long-term performance with polymyxin-B immobilized fiber treatment for septic shock

Introduction

Septic shock remains the main cause of late death of patients admitted to the ICU. Despite recent advances in medical support and treatment, this mortality has not changed significantly. The treatment of direct hemoperfusion using polymyxin-B immobilized fiber (PMX-DHP) has shown that an increase of blood pressure was observed in patients with septic shock caused by Gram-negative infection. The performance time of PMX-DHP is usually 2 hours in Japan. In this study, we investigated the clinical efficacy of the long-term performance of PMX-DHP.

Methods

We treated 10 patients with septic shock caused by Gram-positive infection including MRSA as well as Streptococcus pneumonia and Clostridium using the PMX-DHP treatment.

Results

An increase of blood pressure was observed in eight out of 10 (80%) patients with septic shock. The average performance time of PMX-DHP was 6.5 hours to improve the blood pressure.

Conclusion

Our results suggest that septic shock caused by Gram-positive infection seems to be improved by long-term performance with PMX-DHP treatment.

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Matumoto, N., Suzuki, Y., Kikuchi, S. et al. Clinical efficacy of long-term performance with polymyxin-B immobilized fiber treatment for septic shock. Crit Care 12, P461 (2008). https://doi.org/10.1186/cc6682

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Keywords

  • Blood Pressure
  • Pneumonia
  • Performance Time
  • Septic Shock
  • Emergency Medicine