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  • Meeting abstract
  • Open Access

Characteristics of patients with sepsis and multiple organ failure in the UK

  • 1,
  • 1,
  • 1 and
  • 1
Critical Care20003 (Suppl 1) :P254

https://doi.org/10.1186/cc627

  • Published:

Keywords

  • High Mortality
  • Treatment Modality
  • Emergency Medicine
  • Demographic Data
  • Timely Intervention

Introduction

This study examined the characteristics and ICU outcome of patients admitted with severe sepsis and compared them with patients who develop severe sepsis after admission to the ICU.

Method

The Riyadh Intensive Care Program (RIP) database1989-1996 contains 28094 complete demographic data, daily APACHE II and TISS scores from 21 UK ICUs. 2790 patients retrospectively satisfied the criteria of severe sepsis and multiple organ failure.

Results

See Table.

Conclusion

The timing of development of severe sepsis and multiple organ failure appears to be an important factor for outcome with a significantly higher mortality among those admitted with sepsis. The admission APACHE II score and the score on the day of development of sepsis were lower among those who developed sepsis. This may be attributable to these patients already being in the ICU environment and thus receiving closer monitoring and more timely intervention. This finding may be of importance in the design of future trials to evaluate new treatment modalities.
1

All severe sepsis and multiple organ failure patients

 

Total

Survivors

Non-survivors

P

n (%)

2790

1162 (41.6%)

1628 (58.4%)

 

Mean age (SD)

60.2 (16.7)

58.5 (17.7)

61.5 (15.9)

<0.001

Admission Apache

21.5 (7.6)

19.1 (7.1)

23.2 (7.5)

<0.001

II (SD)

    

Apache II on 1st

22.6 (7.5)

19.7 (6.9)

24.7 (7.2)

<0.001

day of sepsis (SD)

    

No organ

2.3 (0.6)

2.2 (0.5)

2.4 (0.7)

<0.001

failures (SD)

    
2

Differences between those admitted with and those that developed sepsis

 

Admitted with

Developed

P

n (%)

782 (28%)

2008 (72%)

 

Mortality (%)

491 (62.8%)

1137 (56.6)

0.003

Mean age (SD)

59 (17.3)

60.7 (16.5)

0.01

Admission Apache II (SD)

25.8 (7.2)

19.8 (7.0)

<0.001

Day of sepsis Apache II (SD)

25.8 (7.2)

21.4 (7.2)

<0.001

No organ failure (SD)

2.5 (0.7)

2.3 (0.7)

<0.001

Authors’ Affiliations

(1)
Dept of Intensive Care, St George's Hospital, London, SW17 0QT, UK

Copyright

© Current Science Ltd 1999

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