Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow

Table 2 Regional blood flow and oxygen delivery during infusion of vasopressin

Time		300 minutes	360 minutes	480 minutes
Celiac trunk (mL/kg per minute)^a,b
	Group C	11 ± 3	12 ± 2	12 ± 2
	Group V	17 ± 6	23 ± 5^c	23 ± 5^c
	Group S	19 ± 8	17 ± 5	16 ± 4
	Group SV	25 ± 17	31 ± 18^d	30 ± 17^d
Liver flow (mL/kg per minute)^a,b,e
	Group C	36 ± 3	35 ± 5	33 ± 4
	Group V	38 ± 9	31 ± 6^c	33 ± 5^d
	Group S	45 ± 8	37 ± 6^c	35 ± 5^c
	Group SV	43 ± 7	29 ± 6^c	31 ± 6^d
DO₂I PV (mL/kg per minute)^a,b,e
	Group C	2.7 ± 0.4	2.6 ± 0.5	2.6 ± 0.4
	Group V	2.5 ± 0.6	1.2 ± 0.2^c	1.4 ± 0.2^c
	Group S	2.7 ± 0.5	2.2 ± 0.5^d	2.1 ± 0.4^c
	Group SV	3.1 ± 0.7	1.3 ± 0.6^c	1.7 ± 0.4^c
DO₂I HA (mL/kg per minute)^a,b
	Group C	0.3 ± 0.3	0.4 ± 0.3	0.4 ± 0.3
	Group V	0.5 ± 0.2	0.8 ± 0.3	0.8 ± 0.2
	Group S	0.6 ± 0.3	0.6 ± 0.3	0.6 ± 0.3
	Group SV	0.6 ± 0.3	1.0 ± 0.7^c	1.0 ± 0.7^c
DO₂I liver (mL/kg per minute)^a
	Group C	3.2 ± 0.4	3 ± 0.6	3.1 ± 0.5
	Group V	3.0 ± 0.7	2.0 ± 0.5^c	2.2 ± 0.3^c
	Group S	3.3 ± 0.6	2.8 ± 0.6	2.7 ± 0.6^d
	Group SV	3.6 ± 0.8	2.3 ± 0.9^c	2.6 ± 0.9^c
Renal artery (mL/kg per minute)^a,b
	Group C	8.7 ± 1.3	9.3 ± 1.3	9.1 ± 1.5
	Group V	8.9 ± 2.2	7.6 ± 2.3^d	8.9 ± 2.7
	Group S	8.1 ± 3.0	8.8 ± 3.5	9.0 ± 4.0
	Group SV	6.2 ± 2.3	5.4 ± 1.6	7 ± 2.4
DO₂I kidney (mL/kg per minute)^a,e
	Group C	1.1 ± 0.2	1.1 ± 0.3	1.2 ± 0.3
	Group V	1.0 ± 0.2	0.7 ± 0.2^c	0.9 ± 0.3
	Group S	0.7 ± 0.4	0.8 ± 0.5	0.9 ± 0.6^c
	Group SV	0.7 ± 0.2	0.6 ± 0.2	0.8 ± 0.3^d

A continuous infusion of vasopressin (0.06 IU/kg per hour) was started in groups V and SV at t = 300 minutes. Animals in groups C and S received intravenous saline only.
^ap < 0.01 time-group interaction groups V versus C: effect of vasopressin in control animals.
^bp < 0.01 time-group interaction groups SV versus S: effect of vasopressin in septic animals.
^cp < 0.01 compared to t = 300 minutes.
^dp < 0.05 compared to t = 300 minutes.
^ep < 0.05 Mann-Whitney test (area under curve): effect of vasopressin in non-septic versus septic animals.
Celiac trunk: blood flow in the celiac trunk. DO₂I HA: oxygen delivered by the hepatic artery. DO₂I kidney: total oxygen delivered by the left renal artery. DO₂I liver: total oxygen delivery to the liver. DO₂I PV: oxygen delivered by the portal vein. Group C: non-septic control group. Group S: septic control group. Group SV: septic test group treated with vasopressin. Group V: non-septic vasopressin control group. Liver flow: total liver blood flow. Renal artery: blood flow in the left renal artery.

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