Parameter | Sham | Serum control | Anti-RAGE mAb (15 mg/kg) |
---|---|---|---|
Number of mice | 5 | 15 | 15 |
Aerobic Gram-negative bacteria (CFU/g) | 0.6 ± 1.5a | 5,643 ± 1,281 | 4,910 ± 395 |
Aerobic Gram-positive bacteria (CFU/g) | 601 ± 548a | 15,616 ± 6,800 | 11,222 ± 1,873 |
Pathology score (lung, small bowel) | 0.6 ± 0.5 | 3.0 ± 0.9b | 1.8 ± 1.1 |
Wet-to-dry ratio (lung tissue) | 4.6 ± 0.6 | 5.3 ± 0.5 | 5.1 ± 0.6 |