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Table 1 Microbiologic and pathologic findings following anti-RAGE mAb therapy in cecal ligation and puncture

From: Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection

Parameter Sham Serum control Anti-RAGE mAb (15 mg/kg)
Number of mice 5 15 15
Aerobic Gram-negative bacteria (CFU/g) 0.6 ± 1.5a 5,643 ± 1,281 4,910 ± 395
Aerobic Gram-positive bacteria (CFU/g) 601 ± 548a 15,616 ± 6,800 11,222 ± 1,873
Pathology score (lung, small bowel) 0.6 ± 0.5 3.0 ± 0.9b 1.8 ± 1.1
Wet-to-dry ratio (lung tissue) 4.6 ± 0.6 5.3 ± 0.5 5.1 ± 0.6
  1. aP < 0.05 sham versus other groups; bP < 0.005 control versus sham or anti-RAGE mAb. CFU, colony-forming units; mAb, monoclonal antibody; RAGE, receptor for advanced glycation end products.