Monitoring of plasma lipid peroxide level after abdominal aortic reconstruction in humans

Aortic reconstructive surgery is associated with post-ischemic reperfusion and oxidative stress. It is expected that oxidative stress should be self-limiting during healing process in the postoperative period. Lipid hydroperoxides (LHP) are one of oxidative stress markers therefore we evaluated changes in LHP level in the course of uncomplicated healing in patients who underwent abdominal aortic reconstruction. Ten male patients, aged 56–74 years (mean 65.5 ± 6.01) with abdominal aortic aneurysm or aortoiliac occlusive disease were submitted to aortic grafting operation. LHP concentration was measured in blood samples collected via central line prior to (P), at the end of (E) and 1 h, 24 h, 48 h and 72 h after surgery. The results are presented as mean ± SEM. *Nonparametric one-way ANOVA-Kruskal-Wallis test.

LHP concentration was significantly increased at the end of surgery and started to decrease just after 1 h later reaching the initial level within 48 h. The obtained results indicate limitation of the oxidative stress in the course of uncomplicated healing. The results also suggest that LHP level can be used for monitoring of oxidative stress activity in humans.