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Table 2 Patient characteristics in the matched sample

From: Cost-effectiveness of activated protein C in real-life clinical practice

Characteristic All patients (n = 840) Pre-license (n = 420) Post-license (n = 420) P
Demographics     
   Age (yrs) 62.4 ± 14.9 62.7 ± 15.3 62.0 ± 14.4 0.4584
> 60 yrs 61.5 61.4 61.7 0.9435
   Male 62.4 60.7 64.1 0.3187
   Weight (kg) 74.6 ± 17.4 74.1 ± 17.6 75.1 ± 17.1 0.4192
Prior location     0.8676
   Medical or surgical department 40.9 41.9 40.0  
   Emergency department 28.7 27.4 30.0  
   Another acute care hospital 21.2 21.4 21.0  
   Home 9.2 9.3 9.0  
Reason for ICU admission     0.8428
   Medical 69.9 70.7 69.0  
   Surgical 29.0 28.3 29.8  
   Trauma 1.1 1.0 1.2  
Disease severity     
   SAPS II on admission 56.7 ± 18.5 56.8 ± 19.1 56.6 ± 18.0 0.8833
   LOD score at enrolmenta 7.60 ± 2.82 7.51 ± 2.91 7.70 ± 2.73 0.3384
   Organ failure at enrolmenta 3.20 ± 0.83 3.15 ± 0.84 3.25 ± 0.82 0.0676
Acute lung injury 2.1 ± 1.1 2.1 ± 1.1 2.2 ± 1.1 0.1922
Acute renal failure 3.3 ± 1.7 3.3 ± 1.8 3.4 ± 1.7 0.5274
Coagulopathy 0.3 ± 0.6 0.2 ± 0.6 0.3 ± 0.6 0.7368
Acute liver failure 0.3 ± 0.5 0.3 ± 0.5 0.3 ± 0.5 0.5669
Acute cardiovascular Failure 1.6 ± 1.3 1.6 ± 1.3 1.6 ± 1.3 0.6664
   Shock at enrolment 94.3 93.3 95.2 0.2344
Comorbid conditions     
   McCabe     0.4541
0 35.1 34.8 35.4  
1 36.6 34.6 38.7  
2 22.7 24.2 21.2  
3 5.6 6.4 4.7  
   Chronic renal failure 5.9 6.5 5.3 0.4775
   Chronic liver disease 3.5 3.6 3.4 0.8552
   Congestive cardiomyopathy 14.0 14.5 13.5 0.6684
   COPD 15.4 14.7 16.1 0.5743
   Diabetes mellitus 6.5 6.3 6.7 0.7854
   Immunosuppressive treatment 4.8 4.8 4.8 0.9938
   Chemotherapy 2.8 3.1 2.4 0.5259
   Metastatic cancer 5.6 6.3 4.9 0.3761
   Haematological malignancies 2.5 2.6 2.4 0.8208
   HIV 5.9 6.5 5.3 0.3511
Infection site     
   Lung 51.8 51.1 52.5 0.7078
   Intra-abdominal 27.1 27.1 27.1 0.9987
   Urinary tract 10.1 11.1 9.1 0.3417
   CNS 3.3 3.0 3.5 0.7432
  1. Values are expressed mean ± standard deviation or proportions of patients. aNeurological failure excluded. CNS, central nervous system; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; LOD, Logistic Organ Dysfunction; SAPS, Simplified Acute Physiology Score.