From: Cost-effectiveness of activated protein C in real-life clinical practice
Characteristic | All patients (n = 840) | Pre-license (n = 420) | Post-license (n = 420) | P |
---|---|---|---|---|
Demographics | ||||
Age (yrs) | 62.4 ± 14.9 | 62.7 ± 15.3 | 62.0 ± 14.4 | 0.4584 |
> 60 yrs | 61.5 | 61.4 | 61.7 | 0.9435 |
Male | 62.4 | 60.7 | 64.1 | 0.3187 |
Weight (kg) | 74.6 ± 17.4 | 74.1 ± 17.6 | 75.1 ± 17.1 | 0.4192 |
Prior location | 0.8676 | |||
Medical or surgical department | 40.9 | 41.9 | 40.0 | |
Emergency department | 28.7 | 27.4 | 30.0 | |
Another acute care hospital | 21.2 | 21.4 | 21.0 | |
Home | 9.2 | 9.3 | 9.0 | |
Reason for ICU admission | 0.8428 | |||
Medical | 69.9 | 70.7 | 69.0 | |
Surgical | 29.0 | 28.3 | 29.8 | |
Trauma | 1.1 | 1.0 | 1.2 | |
Disease severity | ||||
SAPS II on admission | 56.7 ± 18.5 | 56.8 ± 19.1 | 56.6 ± 18.0 | 0.8833 |
LOD score at enrolmenta | 7.60 ± 2.82 | 7.51 ± 2.91 | 7.70 ± 2.73 | 0.3384 |
Organ failure at enrolmenta | 3.20 ± 0.83 | 3.15 ± 0.84 | 3.25 ± 0.82 | 0.0676 |
Acute lung injury | 2.1 ± 1.1 | 2.1 ± 1.1 | 2.2 ± 1.1 | 0.1922 |
Acute renal failure | 3.3 ± 1.7 | 3.3 ± 1.8 | 3.4 ± 1.7 | 0.5274 |
Coagulopathy | 0.3 ± 0.6 | 0.2 ± 0.6 | 0.3 ± 0.6 | 0.7368 |
Acute liver failure | 0.3 ± 0.5 | 0.3 ± 0.5 | 0.3 ± 0.5 | 0.5669 |
Acute cardiovascular Failure | 1.6 ± 1.3 | 1.6 ± 1.3 | 1.6 ± 1.3 | 0.6664 |
Shock at enrolment | 94.3 | 93.3 | 95.2 | 0.2344 |
Comorbid conditions | ||||
McCabe | 0.4541 | |||
0 | 35.1 | 34.8 | 35.4 | |
1 | 36.6 | 34.6 | 38.7 | |
2 | 22.7 | 24.2 | 21.2 | |
3 | 5.6 | 6.4 | 4.7 | |
Chronic renal failure | 5.9 | 6.5 | 5.3 | 0.4775 |
Chronic liver disease | 3.5 | 3.6 | 3.4 | 0.8552 |
Congestive cardiomyopathy | 14.0 | 14.5 | 13.5 | 0.6684 |
COPD | 15.4 | 14.7 | 16.1 | 0.5743 |
Diabetes mellitus | 6.5 | 6.3 | 6.7 | 0.7854 |
Immunosuppressive treatment | 4.8 | 4.8 | 4.8 | 0.9938 |
Chemotherapy | 2.8 | 3.1 | 2.4 | 0.5259 |
Metastatic cancer | 5.6 | 6.3 | 4.9 | 0.3761 |
Haematological malignancies | 2.5 | 2.6 | 2.4 | 0.8208 |
HIV | 5.9 | 6.5 | 5.3 | 0.3511 |
Infection site | ||||
Lung | 51.8 | 51.1 | 52.5 | 0.7078 |
Intra-abdominal | 27.1 | 27.1 | 27.1 | 0.9987 |
Urinary tract | 10.1 | 11.1 | 9.1 | 0.3417 |
CNS | 3.3 | 3.0 | 3.5 | 0.7432 |