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Table 2 Patient characteristics in the matched sample

From: Cost-effectiveness of activated protein C in real-life clinical practice

Characteristic

All patients (n = 840)

Pre-license (n = 420)

Post-license (n = 420)

P

Demographics

    

   Age (yrs)

62.4 ± 14.9

62.7 ± 15.3

62.0 ± 14.4

0.4584

> 60 yrs

61.5

61.4

61.7

0.9435

   Male

62.4

60.7

64.1

0.3187

   Weight (kg)

74.6 ± 17.4

74.1 ± 17.6

75.1 ± 17.1

0.4192

Prior location

   

0.8676

   Medical or surgical department

40.9

41.9

40.0

 

   Emergency department

28.7

27.4

30.0

 

   Another acute care hospital

21.2

21.4

21.0

 

   Home

9.2

9.3

9.0

 

Reason for ICU admission

   

0.8428

   Medical

69.9

70.7

69.0

 

   Surgical

29.0

28.3

29.8

 

   Trauma

1.1

1.0

1.2

 

Disease severity

    

   SAPS II on admission

56.7 ± 18.5

56.8 ± 19.1

56.6 ± 18.0

0.8833

   LOD score at enrolmenta

7.60 ± 2.82

7.51 ± 2.91

7.70 ± 2.73

0.3384

   Organ failure at enrolmenta

3.20 ± 0.83

3.15 ± 0.84

3.25 ± 0.82

0.0676

Acute lung injury

2.1 ± 1.1

2.1 ± 1.1

2.2 ± 1.1

0.1922

Acute renal failure

3.3 ± 1.7

3.3 ± 1.8

3.4 ± 1.7

0.5274

Coagulopathy

0.3 ± 0.6

0.2 ± 0.6

0.3 ± 0.6

0.7368

Acute liver failure

0.3 ± 0.5

0.3 ± 0.5

0.3 ± 0.5

0.5669

Acute cardiovascular Failure

1.6 ± 1.3

1.6 ± 1.3

1.6 ± 1.3

0.6664

   Shock at enrolment

94.3

93.3

95.2

0.2344

Comorbid conditions

    

   McCabe

   

0.4541

0

35.1

34.8

35.4

 

1

36.6

34.6

38.7

 

2

22.7

24.2

21.2

 

3

5.6

6.4

4.7

 

   Chronic renal failure

5.9

6.5

5.3

0.4775

   Chronic liver disease

3.5

3.6

3.4

0.8552

   Congestive cardiomyopathy

14.0

14.5

13.5

0.6684

   COPD

15.4

14.7

16.1

0.5743

   Diabetes mellitus

6.5

6.3

6.7

0.7854

   Immunosuppressive treatment

4.8

4.8

4.8

0.9938

   Chemotherapy

2.8

3.1

2.4

0.5259

   Metastatic cancer

5.6

6.3

4.9

0.3761

   Haematological malignancies

2.5

2.6

2.4

0.8208

   HIV

5.9

6.5

5.3

0.3511

Infection site

    

   Lung

51.8

51.1

52.5

0.7078

   Intra-abdominal

27.1

27.1

27.1

0.9987

   Urinary tract

10.1

11.1

9.1

0.3417

   CNS

3.3

3.0

3.5

0.7432

  1. Values are expressed mean ± standard deviation or proportions of patients. aNeurological failure excluded. CNS, central nervous system; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; LOD, Logistic Organ Dysfunction; SAPS, Simplified Acute Physiology Score.