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Figure 3 | Critical Care

Figure 3

From: Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment

Figure 3

Effects of hyperoxia on stretch-induced infiltration of macrophage inflammatory protein-2 production and neutrophil influx. (a) Macrophage inflammatory protein-2 (MIP-2) production in bronchoalveolar lavage (BAL) fluid from control, nonventilated mice and from mice ventilated for 5 hours at tidal volume of 30 ml/kg with room air (RA) or hyperoxia (n = 6/group). (b) Myeloperoxidase (MPO) assay of lung tissue from control, nonventilated mice and from mice ventilated for 5 hours at tidal volume of 30 ml/kg with RA or hyperoxia (n = 6/group). L-NAME was given intraperitoneally (15 mg/kg) 1 hour before ventilation. *P < 0.05 versus control, nonventilated mice; †P < 0.05 versus all other groups. Akt, serine/threonine kinase/protein kinase B; OD, optical density; WT, wild-type.

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Critical Care

ISSN: 1364-8535