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Table 1 Different options for adjustment of anticoagulation with citrate

From: Clinical review: Patency of the circuit in continuous renal replacement therapy

Anticoagulant target Pro Con
Calculated [citrate] in filter 3–5 mmol/l Fixed ratio of citrate flow and blood flow Anticoagulation may not be optimal
  No extra monitoring  
  Fixed buffer supply to patient  
[iCa++] postfilter 0.25–0.35 mmol/l Optimal anticoagulation Monitoring of postfilter iCa++
   Adjustment of citrate flow gives varying buffer supply to patient
  1. iCa++, ionized calcium.