Table 1 Different options for adjustment of anticoagulation with citrate

Calculated [citrate] in filter 3–5 mmol/l

Fixed ratio of citrate flow and blood flow

Anticoagulation may not be optimal

No extra monitoring

Fixed buffer supply to patient

[iCa⁺⁺] postfilter 0.25–0.35 mmol/l

Optimal anticoagulation

Monitoring of postfilter iCa⁺⁺

Adjustment of citrate flow gives varying buffer supply to patient