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Table 1 Different options for adjustment of anticoagulation with citrate
From: Clinical review: Patency of the circuit in continuous renal replacement therapy
| Anticoagulant target | Pro | Con |
|---|---|---|
| Calculated [citrate] in filter 3–5 mmol/l | Fixed ratio of citrate flow and blood flow | Anticoagulation may not be optimal |
| No extra monitoring | ||
| Fixed buffer supply to patient | ||
| [iCa++] postfilter 0.25–0.35 mmol/l | Optimal anticoagulation | Monitoring of postfilter iCa++ |
| Adjustment of citrate flow gives varying buffer supply to patient |
