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Table 1 Molecular Adsorbent Recirculation System in acute on chronic liver failure

From: Bench-to-bedside review: Current evidence for extracorporeal albumin dialysis systems in liver failure

   

Improvements

 

Study

Number

Controlled

Biochemical

CVS

CNS

Survival (30 days)a

Stange et al. [7]

13

No

Yes

N/A

Yes

69%

Schmidt et al. [10]

8

No

Yes

Yes

No

50%

Jalan et al. [37]

8

No

Yes

Yes

Yes

50%

Di Campli et al. [38]

13

No

Yes

N/A

Yes

38%

Mitzner et al. [8]

13

Yes

Yes

Yes

No

Yes (37.5% versus 0% at 7 days)

Heemann et al. [9]

23

Yes

Yes

Yes

Yes

Yes (90% versus 55%)

Sen et al. [11]

18

Yes

Yesb

No

Yes

No (45% in both)

Blei [16]

70

Yes

N/A

N/A

Yes

N/A

Laleman et al. [12]

18

Yes

Yesc

Yes

N/A

N/A

  1. Biochemical improvements: statistically significant reduction in bilirubin, bile acids, creatinine, and ammonia. aPercentages indicate uncontrolled survival data; btrend did not reach statistical significance; cbilirubin and bile acids only. CNS, improvement in hemodynamic parameters (mean arterial pressure, heart rate, vasopressor requirements); CNS, decrease in hepatic encephalopathy grade (neurological improvement); N/A, not assessed.
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