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Table 2 Time course of hemodynamic variables and plasma bicarbonate levels

From: The metabolic and renal effects of adrenaline and milrinone in patients with myocardial dysfunction after coronary artery bypass grafting

  

t0

t2

t4

t6

t8

t10

t12

t14

CI (liters per minute per square meter)

ADR

1.9 ± 0.2b

3.3 ± 0.6a

3.2 ± 0.4a

3.3 ± 0.6a

3.2 ± 0.5a

3.1 ± 0.5a

3.3 ± 0.6a

3.5 ± 0.5a

 

MIL

2.0 ± 0.2b

2.6 ± 0.2a

3.0 ± 0.6a

2.9 ± 0.4a

3.1 ± 0.5a

3.1 ± 0.5a

3.5 ± 0.6a

3.3 ± 0.5a

 

CON

3.3 ± 0.4

3.1 ± 0.4

3.3 ± 0.6

3.4 ± 0.6a

3.5 ± 0.8

3.5 ± 0.8a

3.8 ± 0.8a

3.8 ± 1.0a

SvO2 (percentage)

ADR

63.6 ± 5.7b

74.1 ± 7.6a

68.6 ± 6.2

69.9 ± 6.6

69.1 ± 6.7a

69.1 ± 6.7

68.0 ± 4.9

67.2 ± 6.2

 

MIL

65.3 ± 8.5b

68.7 ± 5.4

68.6 ± 9.9

65.4 ± 5.9b

65.4 ± 5.9

68.8 ± 7.7a

66.1 ± 6.6

65.7 ± 6.2

 

CON

74.1 ± 5.5

73.5 ± 5.0

71.9 ± 4.5

71.9 ± 4.5

71.9 ± 4.5

71.2 ± 6.6

71.3 ± 5.3

71.5 ± 5.2

MAP (millimeters of mercury)

ADR

79 ± 8

70 ± 7abc

73 ± 9b

76 ± 6

78 ± 7

80 ± 13

82 ± 10

82 ± 10

 

MIL

80 ± 13

83 ± 12

79 ± 11

79 ± 9

81 ± 7

79 ± 9

82 ± 10

77 ± 8

 

CON

83 ± 8

80 ± 8

86 ± 10

82 ± 11

82 ± 8

82 ± 8.0

80 ± 8

79 ± 9

HR (beats per minute)

ADR

97 ± 11

97 ± 8

97 ± 6

95 ± 10

95 ± 10

96 ± 10

96 ± 11

99 ± 10

 

MIL

92 ± 10

91 ± 12

90 ± 11

101 ± 14a

101 ± 14a

100 ± 11a

102 ± 10a

102 ± 9a

 

CON

95 ± 8

96 ± 5

96 ± 5

98 ± 6

97 ± 6

98 ± 7

99 ± 7a

98 ± 6a

PAP mean (millimeters of mercury)

ADR

24 ± 6

26 ± 4

24 ± 4

24 ± 6

24 ± 6

23 ± 6

23 ± 6

20 ± 6

 

MIL

27 ± 5b

26 ± 5

26 ± 6

26 ± 6.4

24 ± 5

25 ± 5

25 ± 4

23 ± 3

 

CON

23 ± 4

25 ± 5

25 ± 5a

23 ± 5

23 ± 5

21 ± 6

20 ± 7

21 ± 8

CVP (millimeters of mercury)

ADR

14 ± 4

14 ± 4

13 ± 3

13 ± 4

13 ± 4

12 ± 5

12 ± 5

10 ± 4

 

MIL

16 ± 4b

14 ± 3a

14 ± 3

13 ± 4a

12 ± 4a

13 ± 5a

13 ± 4a

12 ± 4a

 

CON

12 ± 4

12 ± 4

12 ± 4

11 ± 4

14 ± 3

10 ± 4

10 ± 3

10 ± 4

HCO3- (millimoles per liter)

ADR

22.6 ± 3.1

20.6 ± 3.7a

20.6 ± 3.6a

21.3 ± 2.9

22.6 ± 2.6

23.3 ± 2.2

23.7 ± 1.9

24.0 ± 1.7bc

 

MIL

22.8 ± 2.4

22.4 ± 2.7

22.7 ± 4.4

22.1 ± 1.9

21.8 ± 2.0a

22.4 ± 2.4

22.3 ± 2.3

22.4 ± 1.9

 

CON

22.5 ± 1.1

22.3 ± 1.1

22.0 ± 1.0a

22.1 ± 1.3

22.0 ± 1.2

22.3 ± 1.2

22.6 ± 1.3

22.5 ± 1.6

  1. The time course of hemodynamics and plasma bicarbonate levels (HCO3-) in patients who presented with myocardial dysfunction (cardiac index [CI] of less than 2.2 liters/minute per square meter despite optimization of mean arterial pressure and filling pressures) upon ICU admission and who were treated with adrenaline (ADR) or milrinone (MIL) and of control patients (CON) not needing inotropic after coronary artery bypass grafting with cardiopulmonary bypass. aSignificant difference (p < 0.05) in comparison with baseline (t0); bsignificant difference (p < 0.05) in comparison with the control group; csignificant difference (p < 0.05) between the adrenaline and the milrinone group. CVP, central venous pressure; HR, heart rate; MAP, mean arterial blood pressure; PAP, pulmonary artery pressure; SvO2, mixed venous oxygen saturation.