Skip to content


Open Access

Intensive insulin therapy versus conventional glycemic control in patients with acute neurological injury: a prospective controlled trial

  • JR Azevedo1,
  • ERM Lima1,
  • RJD Cossetti1 and
  • RP Azevedo1
Critical Care200711(Suppl 3):P83

Published: 19 June 2007


Public HealthBrain InjuryEmergency MedicineHypoglycemiaGlycemic Control


To compare intensive insulin therapy with conventional glycemic control in patients with acute neurological injury, evaluating neurological outcome and morbi-mortality.


Patients with two glycemias above 150 mg/dl 12 hours after admission were randomized to receive intensive insulin therapy (G1) or conventional treatment (G2). We evaluated a subgroup of patients with acute brain injury from July 2004 to June 2006.


G1 patients (n = 31) received 70.5 (45.1–87.5) units insulin/day while G2 patients (n = 19) received 2 (0.6–14.1) units/day (P < 0.0001). The median glycemia was comparable in both groups (P = 0.16). Hypoglycemia occurred in two patients (6.4%) in G1 and in one patient (5.8%) in G2 (P = 1.0). Mortality in G1 was 25.8%, and it was 35.2% in G2 (relative reduction of 27%). Neurological outcome was similar in both groups.


A less strict intensive insulin therapy can reduce hypoglycemia and still maintain its benefits.

Authors’ Affiliations

Hospital São Domingos, Hospital Dr Clementino Moura, São Luiz – MA, Brazil


© BioMed Central Ltd 2007