- Meeting abstract
- Published:
The effect of intraoperative Lasix on sodium excretion following cardiac surgery
Critical Care volume 3, Article number: P210 (2000)
Objective
To determine the effect of intra-operative Lasix on sodium excretion (NaEx) in children following cardiac surgery after cardiopulmonary bypass (CPB).
Methods
Thirty-six children (median age 5.9 months, range 0.06–182 months) underwent corrective cardiac surgery for congenital heart disease (CHD). The patients were divided into two groups. Group A (n = 12) received 1 mg/kg of intravenous Lasix at the end of the surgical operation, Group B did not receive Lasix and acted as the control group. Urine samples were collected over the 1st (t = 0) and 16th (t = 16) postoperative hour and sent with paired blood samples for electrolyte measurements. Sodium excretion (NaEx) and urine volume (ml/kg/h) was compared between the two groups at t = 0 and t = 16 using the Mann-Whitney test. NaEx was calculated by multiplying urine volume by urine Na concentration and expressed as mmoles/kg/h.
Results
There were no significant differences in age, weight, pre-operative renal function, CPB times or underlying heart disease (cyanotic vs acynotic) between the two groups.
NaEx and urine volume were significantly greater at t = 0 in the group that received Lasix (P = 0.013 and P = 0.001 respectively). These differences were no longer present at the 16th postoperative hour (P = 0.67 and P = 0.38 respectively). In both groups sodium excretion correlated with urine volume (r = 0.98).
Conclusion
Although intraoperative Lasix transiently increases sodium excretion and therefore urine volumes in the immediate post operative period it does not appear to offer any advantage by the 16th postoperative hour, a time when renal water and sodium conservation is maximal.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Durward, A., Haq, S., Anderson, D. et al. The effect of intraoperative Lasix on sodium excretion following cardiac surgery. Crit Care 3 (Suppl 1), P210 (2000). https://doi.org/10.1186/cc583
Published:
DOI: https://doi.org/10.1186/cc583