Serum lipids analysis in septic shock patients
© BioMed Central Ltd 2007
Published: 19 June 2007
We conducted a prospective study to analyze serum lipids, glucose, triglycerides and C-reactive protein in septic shock patients to evaluate its relation with outcome.
Prospective observational analysis of septic shock patients.
A 28-bed medico-surgical ICU.
Eighteen patients were analyzed.
Materials and methods
We collected blood samples for analysis on days 1, 3, 6, 9, 12 or until death.
All results are presented as the mean with standard deviation. For analysis we divided patients into survivors and nonsurvivors at day 12. We performed a paired Student t test for differences in continuous variables, and correlation coefficients were determined according to multiple-level regression analysis. P < 0.05 was considered significant.
Our mortality rate was 60%. The two groups had similar APACHE II scores. At day 1 there were no statistical differences for any of the substances analyzed. From day 3 onward, significant differences were found between groups for total cholesterol, HDL fraction, triglycerides, glycemia and C-reactive protein. As independent variables, we found glycemia and triglycerides.
Low levels of cholesterolemia, HDL fraction, hyper-triglyceridemia and hyperglycemia were statistically significantly related to a poor prognosis.