Volume 11 Supplement 3

Fourth International Symposium on Intensive Care and Emergency Medicine for Latin America

Open Access

Serum lipids analysis in septic shock patients

  • AC Nogueira1,
  • S Cappi1,
  • C Valeri1,
  • J Barradas1,
  • V Reze1,
  • D Noritomi1,
  • ER Borges1,
  • A Duarte1,
  • M Lins1,
  • E Comissario1,
  • K Sichieri1,
  • R Curi1,
  • H Takahashi1,
  • M Miranda1,
  • M Bernik1,
  • PA Lotufo1,
  • M Martins1,
  • JB Machado1,
  • A Colombo1 and
  • FG Soriano1
Critical Care200711(Suppl 3):P19

https://doi.org/10.1186/cc5806

Published: 19 June 2007

Objective

We conducted a prospective study to analyze serum lipids, glucose, triglycerides and C-reactive protein in septic shock patients to evaluate its relation with outcome.

Design

Prospective observational analysis of septic shock patients.

Setting

A 28-bed medico-surgical ICU.

Participants

Eighteen patients were analyzed.

Materials and methods

We collected blood samples for analysis on days 1, 3, 6, 9, 12 or until death.

Statistical analysis

All results are presented as the mean with standard deviation. For analysis we divided patients into survivors and nonsurvivors at day 12. We performed a paired Student t test for differences in continuous variables, and correlation coefficients were determined according to multiple-level regression analysis. P < 0.05 was considered significant.

Results

Our mortality rate was 60%. The two groups had similar APACHE II scores. At day 1 there were no statistical differences for any of the substances analyzed. From day 3 onward, significant differences were found between groups for total cholesterol, HDL fraction, triglycerides, glycemia and C-reactive protein. As independent variables, we found glycemia and triglycerides.

Conclusion

Low levels of cholesterolemia, HDL fraction, hyper-triglyceridemia and hyperglycemia were statistically significantly related to a poor prognosis.

Authors’ Affiliations

(1)
Hospital Universitário da USP e Faculdade Medicina USP

Copyright

© BioMed Central Ltd 2007

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