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Table 3 Selected sensitivity analysis

From: Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review

  No. of studies No. of patients Effect size 95% CI Overall effect
(P value)
Heterogeneity
(P value)
Change in MAP    (mm Hg)    
All 12 275 19 (15, 22) < 0.001 < 0.001
n > 20 5 175 18 (13, 22) < 0.001 < 0.001
Pre-PMX MAP < 70 3 41 26 (22, 30) < 0.001 0.85
Pre-PMX MAP ≥ 70 9 234 16 (13, 18) < 0.001 0.07
Center duplication 11 268 18 (15, 21) < 0.001 < 0.001
Change in dopamine/dobutamine dose   (μg/kg per minute)    
Alla 4 96 -1.8 (-3.3, -0.4) 0.01 < 0.001
Pre-PMX MAP <70 1 24 -5.0 (-6.6, -3.4) < 0.001 N/A
Pre-PMX MAP ≥ 70 3 72 -0.8 (-1.2, -0.4) < 0.001 0.33
Change in PaO2/FiO2 ratio    (Units)    
Alla 7 151 32 (23, 41) < 0.001 0.87
Pre-PMX PaO2/FiO2 ratio < 200 2 36 30 (19, 40) < 0.001 0.62
Pre-PMX PaO2/FiO2 ratio ≥200 5 115 40 (20, 60) < 0.001 0.84
Change in endotoxin level    (pg/ml)    
All 17 455 -21.2 (-24.9, -17.5) < 0.001 < 0.001
Excluding MRSA 15 410 -24.1 (-28.0, -20.2) < 0.001 < 0.001
Pre-PMX endotoxin <30 pg/ml 5 97 -9.8 (-12.1, -7.5) < 0.001 0.007
Pre-PMX endotoxin ≥30 pg/ml 12 358 -28.2 (-32.3, -24.1) < 0.001 < 0.001
Pre-PMX endotoxin <40 pg/ml 10 283 -14.9 (-18.7, -11.1) < 0.001 < 0.001
Pre-PMX endotoxin ≥40 pg/ml 7 172 -37.4 (-41.9, -32.8) < 0.001 0.25
Center duplication 6 225 -16.4 (-24.0, -8.9) < 0.001 < 0.001
Mortality    Risk ratio    
All 15 920 0.53 (0.43, 0.65) < 0.001 0.07
RCT 8 354 0.50 (0.37, 0.68) < 0.001 0.12
Parallel non-RCT 7 566 0.55 (0.38, 0.81) 0.002 0.07
Excluding MRSA 13 840 0.55 (0.44, 0.69) < 0.001 0.08
RCT excluding MRSA 6 274 0.55 (0.40, 0.76) < 0.001 0.2
n > 20 7 722 0.56 (0.46, 0.68) < 0.001 0.17
APACHE II score < 25 9 713 0.56 (0.43, 0.73) < 0.001 0.06
APACHE II score ≥ 25 6 207 0.45 (0.30, 0.68) < 0.001 0.25
28- to 30-day mortality only 9 704 0.54 (0.43, 0.68) < 0.001 0.12
Center duplication 8 673 0.61 (0.46, 0.82) 0.001 0.03
  1. aFor outcomes of dopamine/dobutamine dose and PaO2/FiO2 ratio, all included studies had a sample size greater than 20. APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidence interval; MAP, mean arterial pressure; MRSA, methicillin-resistant Staphylococcus aureus; N/A, not applicable; PaO2/FiO2, arterial partial pressure of oxygen/fraction of inspired oxygen; PMX, polymyxin B-immobilized fiber column; RCT, randomized controlled trial.