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Table 2 Characteristics and outcome of severe sepsis patients at Dutch ICUs participating in the NICE registry

From: The influence of volume and intensive care unit organization on hospital mortality in patients admitted with severe sepsis: a retrospective multicentre cohort study

Characteristic/outcome Total population of severe sepsis patients (n = 4,605) Interquartile range over ICUs (n = 28)
Number of patients with severe sepsis 4,605 90.3–239.5
% of total ICU population 13.6 8.0–16.5
   Age (years) 64.1 ± 15.4 (67)a 63.1–66.0b
   Sex (% male) 57.5 55.3–61.6
Severity of illness   
   SAPS II score 47.3 ± 17.8 (45)a 44.7–48.9b
Number of SIRS criteria (%)   
Two 12.8 10.5–16.4
Three 37.5 33.2–39.2
Four 49.6 46.0–54.3
Number of organ dysfunctions (%)   
One 17.2 15.48–23.5
Two 37.0 30.7–41.2
Three 29.1 26.6–32.4
Four 13.1 8.3–15.9
Five 3.6 0.5–5.3
Type of organ dysfunction (%)c   
Cardiovascular 88.5 83.8–90.9
Renal 23.7 8.4–32.0
Respiratory 80.4 75.4–82.5
Haematological 23.3 17.4–27.0
Metabolic 33.0 28.4–37.3
Outcome (%)   
ICU mortality 25.0 21.0–30.1
Hospital mortality 34.7 29.3–41.9
  1. Numbers are based on all patients admitted to ICUs participating in the National Intensive Care Evaluation (NICE) registry with severe sepsis between 1 January 2003 and 30 June 2005. Results are presented for the total population (second column), and the interquartile range over the ICUs is given (third column). aMean ± standard deviation (median). bMean per ICU. cPercentages do not add up to 100, because a patient can have more than one organ dysfunction. ICU, intensive care unit; SAPS, Simplified Acute Physiology Score; SIRS, systemic inflammatory response syndrome.