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Figure 1 | Critical Care

Figure 1

From: Hyperoxia increases ventilator-induced lung injury via mitogen-activated protein kinases: a prospective, controlled animal experiment

Figure 1

Effects of hyperoxia on stretch-induced neutrophil infiltration, macrophage inflammatory protein-2 (MIP-2) production, and microvascular leak in JNK knockout mice. (a) Myeloperoxidase (MPO) assay of lung tissue from control, non-ventilated mice, and mice ventilated for five hours at a tidal volume (VT) of 30 ml/kg with room air (RA) or hyperoxia (n = 5 per group). (b) MIP-2 production in bronchoalveolar lavage (BAL) fluid from control, non-ventilated mice, and mice ventilated for five hours at a VT of 30 ml/kg with RA or hyperoxia (n = 5 per group). (c) Evans blue dye (EBD) analysis of lung tissue from control, non-ventilated mice, and mice ventilated for five hours at a VT of 30 ml/kg with RA or hyperoxia (n = 5 per group). *p < 0.05 versus control, non-ventilated mice; †p < 0.05 versus all other groups. JNK, c-Jun NH2-terminal kinase; OD, optical density; WT, wild-type.

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ISSN: 1364-8535