| | LVHP-S | HVLP-S | HVLP-P | OA | NIR | C |
|---|
| | n = 10 | n = 10 | n = 10 | n = 10 | n = 4 | n = 5 |
|---|
| | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) |
|---|
logIL1 nondependent | 0.1262 (0.1117) | 0.3102 (0.0807) | 0.2479 (0.1472) | 0.2804 (0.1129) | -- | -1.4306 (0.1692) |
logIL1 dependent | 0.1166 (0.1674) | 0.2078 (0.1079) | 0.2784 (0.1748) | 0.2657 (0.1758) | -- | -1.4749 (0.0646) |
logPMI nondependent | 0.0363 (0.1349) | 0.1518 (0.1345) | 0.1725 (0.1255) | 0.1721 (0.1273) | -0.738 (0.1359) | -- |
logPMI dependent | 0.0291 (0.0848) | 0.1545 (0.1286) | 0.2347 (0.1272) | 0.1372 (0.1287) | -0.7697 (0.1276) | -- |
- Results are expressed as mean and standard deviation (SD). Post hoc analysis for IL-1β expression: significant differences found between groups: (i) C versus HVLP-P, C versus HVLP-S, C versus LVHP-S, and C versus OA, p < 0.001; (ii) LVHP-S versus HVLP-P, p = 0.014; (iii) LVHP-S versus HVLP-S, p = 0.019; (iv) LVHP-S versus OA, p = 0.007. Post hoc analysis for PMI: significant differences found between groups: (i) NIR versus HVLP-P, NIR versus HVLP-S, NIR versus LVHP-S, and NIR versus OA, p < 0.001; (ii) LVHP-S versus HVLP-P, p < 0.001; (iii) LVHP-S versus HVLP-S, p = 0.026; (iv) LVHP-S versus OA, p = 0.024. C, control group; HVLP-P, high volume-low positive end-expiratory pressure, prone; HVLP-S, high volume-low positive end-expiratory pressure, supine; IL-1β, interleukin-1-beta; logIL1: logarithmic transformation of the expression of IL-1β mRNA normalized by GAPDH mRNA; logPMI, logarithm of the polymorphonuclear infiltratrion index; LVHP-S, low volume-high positive end-expiratory pressure, supine; NIR, no injury, recruited; OA, oleic acid injury, no ventilation; PMI, polymorphonuclear infiltrate.
