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Figure 4 | Critical Care

Figure 4

From: Effect of positive end-expiratory pressure and tidal volume on lung injury induced by alveolar instability

Figure 4

Pathology in the high Vt/low PEEP and low Vt/high PEEP groups. Representative lung histology from the (a) high tidal volume (Vt)/low positive end-expiratory pressure (PEEP) and the (b) low Vt/high PEEP groups. Morphometric Lung Injury Scores and wet:dry weight ratio are also shown. High Vt/low PEEP caused thickened alveolar walls, numerous neutrophils, and significant intra-alveolar edema. Low Vt/high PEEP ventilation significantly decreased all of the histologic indices of lung injury as compared with the high Vt/low PEEP group. Lung wet:dry weight ratios were not different between groups. Data are expressed as mean ± standard error. *P < 0.05 versus high Vt/Low PEEP group.

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Critical Care

ISSN: 1364-8535