Mechanical ventilation and lung infection in the genesis of air-space enlargement

Table 2 Cardiorespiratory parameters measured in the four groups of piglets before death

Cardiorespiratory parameters	Group				p value
	Control	NVI	VNI	VI
Number of animals	5	6	6	8
pH	7.41 ± 0.04	7.38 ± 0.04	7.40 ± 0.27	7.40 ± 0.10	0.12
PaO₂/FiO₂ (mm Hg)	414 ± 82	385 ± 38	279 ± 130^a	208 ± 113^b,c	<0.001
PaCO₂ (mm Hg)	37 ± 6	41 ± 3	40 ± 7	44 ± 7	0.16
Ppeak (cm H₂O)	19 ± 1	NP	28 ± 14	37 ± 14	0.05
Pplat (cm H₂O)	15 ± 3	NP	20 ± 11	27 ± 10	0.07
Crs (ml/cm H₂O)	25 ± 7	NP	20 ± 6	16 ± 6^a	<0.05
MAP (mmHg)	116 ± 11	106 ± 11	92 ± 12^a	74 ± 24^b,c	0.001

^ap < 0.05 versus control; ^bp < 0.01 versus control; ^cp < 0.05 versus NVI. Data are expressed as mean ± standard deviation. Crs, respiratory compliance; MAP, mean arterial pressure; NP, not performed; NVI, non-ventilated-inoculated piglets; PaCO₂, arterial partial pressure of carbon dioxide; PaO₂/FiO₂, arterial partial pressure of oxygen/fraction of inspired oxygen; Ppeak, maximum peak airway pressure; Pplat, end-inspiratory plateau airway pressure; VI, ventilated-inoculated piglets; VNI, ventilated-non-inoculated piglets.

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