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The effectiveness of octreotide at different doses for sulfonylurea-induced hypoglycemia following overdose
Critical Care volume 11, Article number: P121 (2007)
The aim of the study was to investigate the effectiveness of octreotide at different doses in reducing the hypoglycemic attacks and the need for dextrose in treatment of refractory and recurrence hypoglycemia related to the toxicity of sulfonylurea.
In the study, 40 New Zealand type of rabbits were used weighing between 2,500 and 3,000 g. The rabbits were randomly divided into four groups consisting of 10 animals. All the animals were given gliclazide 100 mg orally. For the treatment of hypoglycemic attacks in Group I, only 15 cm3 50% dextrose (7.5 g) intravenously (i.v.) was used; in Group II, Group III and Group IV octreotide 25 μg, 50 μg and 100 μg single doses were used subcutaneously, respectively. Octreotide was given in Groups II and III and Group IV at the eighth hour (when hypoglycemic attacks onset). Groups II, III and IV were given an additional 15 cm3 50% dextrose (7.5 g) i.v. infusion for each hypoglycemic attack developed. Following the toxic dose, animals were given the amount of dextrose used before and after octreotide administration and the number of hypoglycemic attacks were recorded.
There was a significant difference between Groups I, II, and IV in the number of hypoglycemic attacks and the number of dextrose requirement between 9 and 24 hours (P = 0.001). Groups receiving octreotide showed less hypoglycemic attacks and dextrose requirements than controls.
Our experience suggests that octreotide may be used to reduce the number of refractory and recurrence hypoglycemic attacks developing due to overdose of sulfonylurea; large prospective studies would be needed to validate these findings.
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Gul, M., Cander, B., Girisgin, S. et al. The effectiveness of octreotide at different doses for sulfonylurea-induced hypoglycemia following overdose. Crit Care 11, P121 (2007). https://doi.org/10.1186/cc5281
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