Skip to main content
  • Poster presentation
  • Published:

ANCCADI – Antibiotic Coated Catheter to Decrease Infection: a pilot trial

Background

Nosocomial catheter-related bloodstream infections (CR-BSI) have been associated with increased morbidity and possibly increased mortality in critically ill patients. Central venous catheters impregnated with rifampin and minocycline (RM) have been shown to decrease rates of colonization and CR-BSI when compared with controls and with the chlorhexidine/silver sulfadiazine catheter. However, recent randomized trials challenged the clinical impact of such catheters, showing decreased rates in colonization but not in CR-BSI. We designed this pilot trial to compare the rates of colonization and CR-BSI in RM catheters and controls in a Brazilian population of critically ill patients.

Methods

A prospective, nonrandomized, controlled clinical trial was conducted in one medico-surgical 19-bed ICU. Adult patients needing a double or triple central venous catheter were sequentially assigned in permuted blocks of five to undergo insertion of a control or RM-impregnated catheter. After removal, all tips were cultured by the roll-plate method in association with one or two peripheral blood cultures. Rates of colonization and CR-BSI were recorded and compared.

Results

Of 120 catheters inserted, 100 could be evaluated for colonization and CR-BSI. Forty-nine in the uncoated group and 51 in the coated group. Clinical characteristics of patients and risk for infection were similar in the two groups, use of propofol was more frequent in the uncoated group and the presence of a vascular device, other than the study catheter, was more frequent in the antibiotic-coated group. Three RM-coated catheters (5.9%) were colonized compared with nine (18.4%) control catheters (relative risk, 0,28; 95% confidence interval, 0.07–1.096; P = 0.05). Three cases of CR-BSI (5.9%) occurred in patients who received RM catheters compared with five in the control group (10.2%). There was no significant differences in the incidence of CR-BSI between RM-coated and uncoated catheters. Uncoated catheters were more frequently colonized but this difference just failed to show statistical significance. When the duration of catheter placement were taken into consideration, Kaplan–Meier analysis showed no significant differences in the risk of colonization or CR-BSI between RM-coated and uncoated catheters. Rates of CR-BSI were seven per 1,000 catheter-days in the RM-coated group compared with 11.4 per 1,000 catheter-days in the uncoated group (P = 0.7). Gram-positive and Gram-negative organisms were similarly responsible for colonizing catheters in our study; there was no difference in rates of colonization by Candida species.

Conclusion

In this pilot study, we showed a trend toward lower rates of colonization in RM-coated catheters when compared with uncoated control catheters. The incidence and rates of CR-BSI were similar in the two groups, probably because of a small number of catheters studied. Development of a prospective randomized trial with a larger number of patients is underway to confirm or refute these results.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kurtz, P., Kalichsztein, M., Nobre, G. et al. ANCCADI – Antibiotic Coated Catheter to Decrease Infection: a pilot trial. Crit Care 11 (Suppl 2), P81 (2007). https://doi.org/10.1186/cc5241

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/cc5241

Keywords