Skip to main content

Table 5 Hyperlactatemia during CPB and postoperative outcome

From: Hyperlactatemia during cardiopulmonary bypass: determinants and impact on postoperative outcome

  Univariate analysis (Student's t test) Correcteda values
Outcome variable No HL (n = 443) HL (n = 27) p P
Peak serum creatinine (mg/dl) 1.3 ± 1.1 2.1 ± 1.4 0.001 0.45
MV time (hours) 22.6 ± 55 57.4 ± 68 0.015 0.41
ICU stay (days) 2.5 ± 3.4 5.3 ± 5.4 0.012 0.04
  Univariate analysis (RR) Correctedb values
Outcome variable No HL (n = 443) HL (n = 27) RR (95% CI) OR (95% CI)
Prolonged (> 7 days) ICU stay 18 (4.1%) 5 (18.5%) 5.3 (1.8–15.8) 4.2 (1.04–17)
Prolonged (> 48 hours) MV 21 (4.7%) 9 (33.3%) 10 (4–25) 4.9 (1.6–15)
Surgical revision 19 (4.3%) 5 (18.5%) 5.1 (1.7–14.8) 2.5 (0.6–9.5)
Intra-aortic balloon pump 2 (0.4%) 3 (11.1%) 27.5 (4.4–172) 23 (2.7–207)
Atrial fibrillation 75 (17%) 9 (33.3%) 2.4 (1.06–5.6) 1.6 (0.6–4.1)
Severe lung dysfunction 6 (1.3%) 2 (7.4%) 5.8 (1.1–30.3) 0.8 (0.1–8.5)
Sepsis 9 (2%) 3 (11.1%) 6 (1.5–23.7) 3.6 (0.6–21)
Composite morbidity index 36 (8.1%) 9 (33.3%) 5.6 (2.4–13.5) 2.9 (1.03–8.5)
Hospital mortality 5 (1.1%) 3 (11.1%) 10.9 (2.5–48) 2.5 (0.37–18)
  1. aValues obtained including preoperative serum creatinine value, active endocarditis, and CPB duration into a multivariate linear regression; bvalues obtained including preoperative serum creatinine value, active endocarditis, and CPB duration into a multivariate logistic regression. CI, confidence interval; CPB, cardiopulmonary bypass; HL, hyperlactatemia; ICU, intensive care unit; MV, mechanical ventilation; OR, odds ratio; RR, relative risk.