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Figure 1 | Critical Care

Figure 1

From: Children undergoing cardiac surgery for complex cardiac defects show imbalance between pro- and anti-thrombotic activity

Figure 1

Role of thrombin in the coagulation system. Thrombin has a central role in different interactions of the coagulation system as shown. Cleavage of prothrombin fragment 1+2 (F1+2) from prothrombin results in thrombin formation. Thrombin production leads to tissue factor pathway inhibitor (TFPI) upregulation, which inhibits tissue factor (TF) activity. Monocyte chemoattractant protein-1 (MCP-1) production is also increased via thrombin interaction.

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Critical Care

ISSN: 1364-8535