Skip to main content
Figure 1 | Critical Care

Figure 1

From: Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury

Figure 1

The role of the protein C pathway in the endothelial cell. APC modulates endothelial phenotype by inhibiting thrombin production, direct antiapoptotic effects, and suppression of NF-κB subunits and therefore decreased inflammatory cell adhesion. APC, activated protein C; ICAM, intercellular adhesion molecule; NF-κB, nuclear factor-κB; TNF, tumor necrosis factor; VCAM, vascular cell adhesion molecule. Reprinted with permission from the American Society for Biochemistry and Molecular Biology [25].

Back to article page

Critical Care

ISSN: 1364-8535