Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome

Fialkow, Léa; Fochesatto Filho, Luciano; Bozzetti, Mary C; Milani, Adriana R; Rodrigues Filho, Edison M; Ladniuk, Roberta M; Pierozan, Paula; de Moura, Rafaela M; Prolla, João C; Vachon, Eric; Downey, Gregory P

doi:10.1186/cc5090

Critical Care

Table 3 Detailed description of the surgical patients

From: Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome

Patient	Group
Uncomplicated sepsis (n = 8)
	Diagnosis	Site of infection	Microorganism	Material	Surgery
1	Pneumonia/Intracerebral haemorrhage	Respiratory	Pseudomonas aeruginosa	Sputum	Craniotomy
2	Pneumonia/COPD	Respiratory	P. aeruginosa	Sputum	Aortic-femoral bypass
3	Pneumonia/Perforated ulcer	Abdominal	Candida albicans	Ascites	Laparatomy
4	Cholangitis/UTI	Abdominal/Urinary	Enterococcus sp/Escherichia coli	Blood/Urine	Exploratory laparotomy
5	Pneumonia/Peritonitis/Colonic perforation due to colonoscopy	Respiratory/Abdominal	Enterobacter sp/Not identified	Sputum/Blood	Exploratory laparotomy
6	Cholecystitis	Abdominal	Enterococcus sp	Blood	Cholecystectomy
7	Pneumonia/Intracerebral haemorrhage	Respiratory	Enterobacter sp, Haemophilus sp, and Staphylococcus aureus	Sputum	Craniotomy
8	Pneumonia/Stroke/UTI/Celulitis	Respiratory/Urinary/Skin	Not identified/Enterobacter sp/S. aureus	Sputum/Urine/Skin secretion	Abdominal aortic aneurysm repair
Septic shock (n = 11)
	Diagnosis	Site of infection	Microorganism	Material	Surgery
1	Pneumonia	Respiratory/Catheter	P. aeruginosa/S. aureus	Sputum/Catheter	Carotid aneurysm repair
2	Diverticulitis/UTI	Abdominal/Urinary	Not identified/Candida sp	Blood/Urine	Small bowel resection with anastomosis
3	Perforated peptic ulcer/Cirrhosis/Alcohol abuse	Abdominal	S. aureus	Blood/Ascites	Laparatomy
4	Septic arthritis (Hip)	Joint	Streptococcus agalactiae	Joint fluid	Surgical drainage
5	Pneumonia/Head trauma (subdural haematoma)	Respiratory	Not identified	Sputum/Blood	Craniotomy
6	Pyelonephritis/Nephrolitiasis/Neurogenic bladder	Urinary	Staphylococcus sp/P. aeruginosa	Blood/Urine	Nephrectomy and abscess drainage
7	Perforated peptic ulcer	Abdominal	S. aureus, Streptococcus viridans, and Enterobacter sp	Ascites	Exploratory laparotomy
8	Pneumonia/Endocarditis/Intracerebral haemorrhage	Respiratory/Heart	Pseudomonas sp/Not identified	Sputum/Blood	Craniotomy
9	Pneumonia/COPD/UTI Oesophageal laceration	Respiratory/Urinary	S. aureus and Acinetobacter sp/E. coli	Sputum/Urine	Oesophageal laceration repair
10	Cholangitis	Abdominal	E. coli	Blood	Exploratory laparotomy
11	Peritonitis/Perforated peptic ulcer	Abdominal	Enterococcus sp, Candida sp, and S. aureus	Ascites	Laparotomy
Sepsis-induced ARDS (n = 9)
	Diagnosis	Site of infection	Microorganism	Material	Surgery
1	Cholangitis	Abdominal	Klebsiella pneumoniae	Ascites	Hepatic artery aneurysm ligation
2	Diverticulitis	Abdominal	E. coli	Blood	Small bowel resection with anastomosis
3	Pneumonia	Respiratory	P. aeruginosa	Sputum	Pleurostomy closure
4	Pneumonia	Respiratory	Staphylococcus coag neg	Blood	C-section
5	Septic arthritis	Hip joint	Staphylococcus haemolyticus	Blood	Hip drainage
6	UTI/Intestinal fistula	Urinary	Candida sp and Enterococcus sp	Blood and urine	Intestinal fistula closure
7	Pneumonia/UTI/Peripheral vascular disease	Respiratory/Urinary/Skin	Not identified/Candida sp/S. aureus	Sputum/Urine/Skin secretion	Above-knee amputation
8	Septic arthritis	Hip joint	Stenotroptomonas maltophilia and Staphylococcus coag neg/S. agalactiae	Blood and joint fluid	Hip drainage
9	Cholecystitis	Abdominal/Catheter	E. coli/S. aureus	Blood/Catheter	Cholecystectomy
Mechanical ventilation (n = 9)
	Diagnosis	Surgery
1	Head trauma (subdural haematoma)	Craniotomy
2	Intracerebral haemorrhage	Craniotomy
3	Head trauma (subdural haematoma)	Craniotomy
4	Head trauma (subdural haematoma)	Craniotomy
5	Head trauma (epidural haematoma)	Craniotomy
6	Uterine leyomioma	Hysterectomy
7	Abdominal trauma	Exploratory laparotomy
8	Head trauma (subdural haematoma)	Craniotomy
9	Intracerebral haemorrhage	Craniotomy
Controls (n = 11)
	Surgery
1	Humeral prostheses
2	Inguinal hernia repair
3	Septoplasty
4	Inguinal hernia repair
5	Arthrodesis (tibia-tarsus)
6	Tibial osteosynthesis
7	Septoplasty
8	Diaphragmatic hernia repair and laparoscopic fundoplication
9	Iliofemoral bypass
10	Incisional hernia repair
11	Septoplasty

ARDS, acute respiratory distress syndrome; COPD, chronic obstructive respiratory disease; UTI, urinary tract infection.

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