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Table 1 Select components of the Surviving Sepsis Campaign [7]

From: Drotrecogin alfa (activated) should not be used in patients with severe sepsis and low risk for death

â–ª Early goal-directed resuscitation

â–ª Appropriate diagnostic studies prior to antibiotics

â–ª Early broad-spectrum antibiotics

â–ª Narrowing antibiotic therapy based on microbiology and clinical data

â–ª Source control

â–ª Stress-dose steroids for septic shock

â–ª DrotAA for patients with severe sepsis and high risk for death

▪ Target hemoglobin values of 7–9 g/dL in absence of coronary artery disease or acute hemorrhage

â–ª Lung protective ventilation for ALI/ARDS

â–ª Semirecumbent bed position

â–ª Protocols for weaning and sedation/analgesia

â–ª Avoidance of neuromuscular blockers

â–ª Maintenance of blood glucose <150 mg/dL

â–ª Deep vein thrombosis/stress ulcer prophylaxis

  1. ALI/ARDS = Acute lung injury/acute respiratory distress syndrome