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Table 1 Changes in hemodynamic variables in endotoxemic sheep.

From: Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemia

Variable

Group

T1

T2

T3

T4

T5

T6

MPAP (mmHg)

Control

18 ± 1

25 ± 1‡‡‡

26 ± 1

26 ± 1

26 ± 1

25 ± 1

 

AVP

19 ± 1

27 ± 1‡‡‡

27 ± 2

27 ± 2

26 ± 2

27 ± 3

 

AVP-Dobu

20 ± 1

25 ± 1‡‡‡

25 ± 1

25 ± 1

25 ± 1

24 ± 1

PVRI (dyne.s.cm-5·m2)

Control

99 ± 8

138 ± 18

142 ± 14

145 ± 13

146 ± 11

140 ± 10

 

AVP

98 ± 12

124 ± 18

184 ± 34*

173 ± 37

179 ± 35

176 ± 35

 

AVP-Dobu

107 ± 9

125 ± 12

191 ± 30*

163 ± 16

132 ± 16

133 ± 16

CVP (mmHg)

Control

5 ± 0

7 ± 1

7 ± 0

6 ± 1

6 ± 1

6 ± 1

 

AVP

5 ± 1

8 ± 0

8 ± 1

8 ± 1

7 ± 1

8 ± 1

 

AVP-Dobu

6 ± 1

7 ± 1

9 ± 1

8 ± 1

6 ± 1

6 ± 1

PAOP (mmHg)

Control

11 ± 1

12 ± 1

12 ± 1

12 ± 1

12 ± 1

12 ± 1

 

AVP

9 ± 0

13 ± 1

15 ± 1

15 ± 1

15 ± 1

14 ± 1

 

AVP-Dobu

11 ± 1

12 ± 2

15 ± 2

15 ± 1

14 ± 1

12 ± 1

SVI (ml beat-1 m-2)

Control

69 ± 3

60 ± 3

61 ± 3

62 ± 3

62 ± 3

62 ± 2

 

AVP

61 ± 3

62 ± 4

48 ± 5

48 ± 6

47 ± 3

47 ± 3

 

AVP-Dobu

70 ± 3

63 ± 4

49 ± 5

59 ± 6

63 ± 5

64 ± 5††

LVSWI (g m-1 m2)

Control

79 ± 5

57 ± 3

59 ± 3

61 ± 3

64 ± 3

60 ± 2

 

AVP

75 ± 3

57 ± 4

62 ± 11

62 ± 11

68 ± 12

70 ± 12

 

AVP-Dobu

76 ± 4

56 ± 5‡‡

59 ± 6

80 ± 9

95 ± 7**††§

94 ± 8**†§

RVSWI (g m-1 m2)

Control

12 ± 1

15 ± 1

16 ± 1

17 ± 1

17 ± 1

16 ± 1

 

AVP

12 ± 1

16 ± 1

12 ± 2*

11 ± 1*

13 ± 1

13 ± 1

 

AVP-Dobu

13 ± 0

15 ± 2

11 ± 2**

14 ± 2

16 ± 2

17 ± 2

  1. AVP, arginine vasopressin; AVP-Dobu, group treated with AVP and dobutamine; MPAP, mean pulmonary arterial pressure; PVRI, pulmonary vascular resistance index; CVP, central venous pressure; PAOP, pulmonary artery occlusion pressure; SVI, stroke volume index; LVSWI, left ventricular stroke work index; RVSWI, right ventricular stroke work index; T1, healthy baseline; T2, endotoxemic baseline; T3, AVP or placebo; T4, T5, T6, AVP + dobutamine 2, 5 and 10 μg kg-1 min-1 or placebo, respectively. *p < 0.05 versus control, **p < 0.01 versus control, p < 0.05 versus AVP, ††p < 0.01 versus AVP, p < 0.05 versus T1, ‡‡p < 0.01 versus T1, ‡‡‡p < 0.001 versus T1, §p < 0.05 versus T4.