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Table 3 Effect of non-specific therapy on coagulation and fibrinolysis

From: Bench-to-bedside review: Thrombocytopenia-associated multiple organ failure – a newly appreciated syndrome in the critically ill

Plasma infusion

Plasma exchange

Restores procoagulant factors

Restores procoagulant factor homeostasis

Restores anticoagulant factors (protein C, antithrombin III, TFPI)

Restores anticoagulant factor homeostasis (protein C, antithrombin III, TFPI)

Restores prostacyclin

Restores prostacyclin homeostasis

Restores tPA

Restores tPA homeostasis

Restores ADAMTS 13

Restores ADAMTS 13 homeostasis

 

Removes ADAMTS 13 inhibitors

 

Removes ultra-large vWF multimers

 

Removes tissue factor

 

Removes excess PAI-1

  1. PAI, plasminogen activator inhibitor type I; TFPI, tissue factor pathway inhibitor; tPA, tissue plasminogen activator; vWF, von Willebrand factor.
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Critical Care

ISSN: 1364-8535