Figure 6
From: Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction
Markers of organ dysfunction. Plasma concentrations of alanine aminotransferase (ALT) (a), aspartate aminotransferase (AST) (b), and creatinine (c) in mice treated with intraperitoneal PBS followed 14 hours later by 6 hours of spontaneous breathing (PBS) or mechanical ventilation (MV), and in mice treated with intraperitoneal lipopolysaccharide (LPS; 1 μg/kg) followed 14 hours later by either spontaneous breathing (LPS) or 6 hours of mechanical ventilation (LPS + MV). In all groups receiving mechanical ventilation, the tidal volume was 10 ml/kg and the fraction of inspired oxygen was 0.21. *p < 0.05.