Figure 4
From: Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction
Tissue response. Representative lung tissue sections stained with hematoxylin and eosin, from mice treated with intraperitoneal PBS followed 14 hours later by 6 hours of spontaneous breathing (PBS) (a, b) or mechanical ventilation (MV) (c, d), and from mice treated with intraperitoneal lipopolysaccharide (LPS; 1 μg/kg) followed 14 hours later by either spontaneous breathing (LPS) (e, f) or 6 hours of mechanical ventilation (LPS + MV) (g, h). The arrows show neutrophil in the alveolar walls. Note the slight thickening of the alveolar walls in (h). The right column shows magnifications of the indicated areas in the left column. Magnifications: left column, ×200; right column, ×400. In all groups receiving mechanical ventilation, the tidal volume was 10 ml/kg and the fraction of inspired oxygen was 0.21.