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Figure 5 | Critical Care

Figure 5

From: The early responses of VEGF and its receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival

Figure 5

Intestinal ischemia reperfusion (IIR)-induced alveolar epithelial cell death is negatively correlated with vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR)-1 expression. (a) Double fluorescents staining TUNEL (red)-cytokeratin (green). An increased number of epithelial cells (in green) undergoing cell death (in red) was detected in the IIR group. Slides shown are representatives of four animals from each group. (b) Epithelial cell death index was quantified by TUNEL-cytokeratin double positive cells over cytokeratin positive cells of each field (ten fields were quantified from each animal); *p < 0.05 compared with the control group; #p < 0.05 compared with the sham group. (c) Relationship between TUNEL-positive-epithelial cells and VEGF-positive cells. (d) Relationship between TUNEL-positive-epithelial cells and VEGFR-1-positive cells.

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Critical Care

ISSN: 1364-8535