Table 2 Mitochondrial respiration and maximal ATP production in the muscle and the kidney at the end of the experiment
From: Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function
Substrate | Group | Muscle | Kidney | ||
|---|---|---|---|---|---|
n | Median (range) | n | Median (range) | ||
Glutamate | |||||
State 3 | Endotoxic | 8 | 174 (93–114) | 7 | 93 (56–129) |
Control | 9 | 223 (67–494) | 8 | 116 (49–165) | |
State 4 | Endotoxic | 8 | 18 (13–42) | 7 | 22 (13–40) |
Control | 9 | 20 (11–49) | 8 | 18 (11–27) | |
Maximal ATP production | Endotoxic | 8 | 328 (187–940) | 7 | 184 (74–431) |
Control | 9 | 606 (153–1233) | 8 | 221 (133–485) | |
Respiratory control ratio | Endotoxic | 8 | 8.1 (6.7–11.8) | 7 | 4.0 (2.3–6.3) |
Control | 9 | 8.3 (6.0–14.5) | 8 | 5.4 (3.7–7.1) | |
Succinate | |||||
State 3 | Endotoxic | 8 | 269 (167–467) | 7 | 194 (129–269) |
Control | 9 | 307 (129–579) | 8 | 230 (107–269) | |
State 4 | Endotoxic | 8 | 56 (36–82) | 7 | 67 (33–98) |
Control | 9 | 62 (31–129) | 8 | 60 (36–78) | |
Maximal ATP production | Endotoxic | 8 | 513 (356–944) | 7 | 460 (169–707) |
Control | 9 | 611 (421–1164) | 8 | 469(193–1292) | |
Respiratory control ratio | Endotoxic | 8 | 4.9 (2.9–7.0) | 7 | 3.3 (2.0–3.9) |
Control | 9 | 4.1 (3.6–8.8) | 8 | 3.6 (3.0–3.9) | |
Ascorbate/N,N,N',N'-tertamethyl-p-phenyldiamine | |||||
State 3 | Endotoxic | 8 | 271 (189–401) | 7 | 134 (98–191) |
Control | 9 | 316 (156–412) | 8 | 150 (116–401) | |
State 4 | Endotoxic | 8 | 151 (100–200) | 7 | 91 (49–134) |
Control | 9 | 147 (76–254) | 8 | 99 (62–169) | |
Respiratory control ratio | Endotoxic | 8 | 1.9 (1.4–2.0) | 7 | 1.6 (1.4–2.7) |
Control | 9 | 1.7 (1.4–2.9) | 8 | 1.8 (1.5–2.8) |