|
Parameter
|
Treatment group
|
|---|
| |
Placebo (n = 709)
|
Drotrecogin alfa (activated) (n = 743)
|
P value
|
|---|
|
Protein S activity
|
|
Baseline
|
39% (24, 59)
|
35% (22, 57)
|
0.09
|
|
Day 1
|
36% (23, 57)
|
35% (22, 56)
|
0.41
|
|
Day 1 change
|
0% (-9, 7)
|
0% (-10, 9)
|
0.59
|
|
Antithrombin III
|
|
Baseline
|
60% (45, 75)
|
59% (44, 75)
|
0.50
|
|
Day 1
|
59% (45, 75)
|
59% (44, 76)
|
0.61
|
|
Day 1 change
|
0% (-10, 9)
|
0% (-8, 7)
|
0.88
|
|
IL-6
|
|
Baseline
|
436 (126, 2338)
|
523 (156, 2701)
|
0.08
|
|
Day 1
|
199 (68, 717)
|
211 (77, 685)
|
0.44
|
|
Day 1 change
|
-157 (-1073, -6)
|
-225 (-1922, -27)
|
0.006
|
- Summary statistics reported as the median (25th percentile, 75th percentile), and P values from Wilcoxon rank-sum tests (P < 0.05 significant).
