Table 4 Baseline and day 1 values for protein S, antithrombin III, and IL-6 by treatment group in the PROWESS trial
Parameter | Treatment group | ||
|---|---|---|---|
Placebo (n = 709) | Drotrecogin alfa (activated) (n = 743) | P value | |
Protein S activity | |||
Baseline | 39% (24, 59) | 35% (22, 57) | 0.09 |
Day 1 | 36% (23, 57) | 35% (22, 56) | 0.41 |
Day 1 change | 0% (-9, 7) | 0% (-10, 9) | 0.59 |
Antithrombin III | |||
Baseline | 60% (45, 75) | 59% (44, 75) | 0.50 |
Day 1 | 59% (45, 75) | 59% (44, 76) | 0.61 |
Day 1 change | 0% (-10, 9) | 0% (-8, 7) | 0.88 |
IL-6 | |||
Baseline | 436 (126, 2338) | 523 (156, 2701) | 0.08 |
Day 1 | 199 (68, 717) | 211 (77, 685) | 0.44 |
Day 1 change | -157 (-1073, -6) | -225 (-1922, -27) | 0.006 |