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Table 4 Baseline and day 1 values for protein S, antithrombin III, and IL-6 by treatment group in the PROWESS trial

From: Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome

Parameter Treatment group
  Placebo (n = 709) Drotrecogin alfa (activated) (n = 743) P value
Protein S activity
   Baseline 39% (24, 59) 35% (22, 57) 0.09
   Day 1 36% (23, 57) 35% (22, 56) 0.41
   Day 1 change 0% (-9, 7) 0% (-10, 9) 0.59
Antithrombin III
   Baseline 60% (45, 75) 59% (44, 75) 0.50
   Day 1 59% (45, 75) 59% (44, 76) 0.61
   Day 1 change 0% (-10, 9) 0% (-8, 7) 0.88
IL-6
   Baseline 436 (126, 2338) 523 (156, 2701) 0.08
   Day 1 199 (68, 717) 211 (77, 685) 0.44
   Day 1 change -157 (-1073, -6) -225 (-1922, -27) 0.006
  1. Summary statistics reported as the median (25th percentile, 75th percentile), and P values from Wilcoxon rank-sum tests (P < 0.05 significant).