|
Parameter
|
Baseline protein C ≤ 40% of normal
|
Baseline protein C 41–80% of normal
|
Baseline protein C >80% of normal
|
|---|
| |
Placebo (n = 285)
|
DrotAA (n = 330)
|
Placebo (n = 385)
|
DrotAA (n = 379)
|
Placebo (n = 105)
|
DrotAA (n = 90)
|
|---|
|
APACHE II score*
|
26.1 ± 8.1
|
25.6 ± 7.7
|
24.3 ± 7.8
|
23.9 ± 7.5
|
23.9 ± 7.3
|
23.8 ± 6.7
|
|
Age (years)
|
61.4 ± 16.9
|
60.9 ± 17.1
|
60.0 ± 16.7
|
59.9 ± 17.8
|
61.9 ± 14.6
|
61.4 ± 16.4
|
|
Log IL-6*
|
7.4 ± 2.1
|
7.5 ± 2.2
|
6.1 ± 2.0
|
6.2 ± 2.0
|
4.7 ± 1.8
|
4.7 ± 1.7
|
|
Urosepsis (%)
|
9.8
|
10.3
|
12.2
|
8.7
|
3.8
|
14.4
|
|
Comorbiditesa (%)**
|
16.5
|
15.5
|
20.0
|
19.8
|
35.2
|
34.4
|
|
Dependenciesb (%)**
|
25.3
|
21.8
|
29.6
|
29.3
|
38.1
|
33.3
|
|
Septic shock (%)**
|
76.8
|
80.6
|
72.2
|
66.0
|
59.0
|
55.6
|
|
28-day mortality (%)
|
41.8
|
27.6
|
24.9
|
24.0
|
26.7
|
15.6
|
- DrotAA, drotrecogin alfa (activated). Patients were prospectively categorized on the basis of their baseline protein C activity levels (normal, >80%; deficient, 41–80% of normal; and severely deficient, ≤ 40% of normal). aAny chronic health points from the (APACHE) II classification system. bPatient considered dependent if they were dependent in one or more activities on the Activities of Daily Living scale [16]. *Significantly different between protein C classes (P < 0.05) using Spearman rank-correlation with baseline protein C levels. **Significant (P < 0.05) association with baseline protein C levels using Wilcoxon rank-sum tests comparing the "yes" versus "no" classifications
