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Table 2 Protein C and additional measures as risk factors in PROWESS placebo patients

From: Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome

Parameter Baseline protein C Baseline and day 1 protein C
  Odds ratioa 95% confidence interval P value Odds ratioa 95% confidence interval P value
APACHE II scoreb 1.31 1.16–1.48 <0.0001 1.33 1.17–1.51 <0.0001
Agec 1.17 1.10–1.24 <0.0001 1.17 1.10–1.24 <0.0001
Log IL-6d 1.48 1.22–1.80 <0.0001 1.30 1.06–1.60 0.010
Comorbidity 2.00 1.32–3.03 0.001 1.80 1.17–2.78 0.008
Dependenciese 1.70 1.17–2.46 0.006 1.81 1.23–2.68 0.003
Urosepsis 0.47 0.25–0.87 0.020 0.42 0.22–0.79 0.008
Baseline protein C ≤ 40% 1.75 1.21–2.53 0.003 2.74 1.75–4.30 <0.0001
Baseline protein C ≤ 40% and day 1 protein C >40% - - - 0.43 0.20–0.93 0.030
Baseline protein C >40% and day 1 protein C 10% decrease - - - 1.87 1.12–3.11 0.020
  1. APACHE, Acute Physiology and Chronic Health Evaluation. All patients with baseline protein C values from the PROWESS trial (n = 1574) were included in analyses. Risk factors used were previously found to be significant predictors of outcome in analyses of data from PROWESS [15]. aBased on multivariable logistic regression; values >1 indicate increased risk, values <1 indicate lower risk. bPer 5-point increase in baseline score. cPer 5-year increase in age. dPer 10 times increase in baseline IL-6. ePatient was considered dependent if they were dependent in one or more activities on the Activities of Daily Living scale [16].