|
Parameter
|
Baseline protein C
|
Baseline and day 1 protein C
|
|---|
| |
Odds ratioa
|
95% confidence interval
|
P value
|
Odds ratioa
|
95% confidence interval
|
P value
|
|---|
|
APACHE II scoreb
|
1.31
|
1.16–1.48
|
<0.0001
|
1.33
|
1.17–1.51
|
<0.0001
|
|
Agec
|
1.17
|
1.10–1.24
|
<0.0001
|
1.17
|
1.10–1.24
|
<0.0001
|
|
Log IL-6d
|
1.48
|
1.22–1.80
|
<0.0001
|
1.30
|
1.06–1.60
|
0.010
|
|
Comorbidity
|
2.00
|
1.32–3.03
|
0.001
|
1.80
|
1.17–2.78
|
0.008
|
|
Dependenciese
|
1.70
|
1.17–2.46
|
0.006
|
1.81
|
1.23–2.68
|
0.003
|
|
Urosepsis
|
0.47
|
0.25–0.87
|
0.020
|
0.42
|
0.22–0.79
|
0.008
|
|
Baseline protein C ≤ 40%
|
1.75
|
1.21–2.53
|
0.003
|
2.74
|
1.75–4.30
|
<0.0001
|
|
Baseline protein C ≤ 40% and day 1 protein C >40%
|
-
|
-
|
-
|
0.43
|
0.20–0.93
|
0.030
|
|
Baseline protein C >40% and day 1 protein C 10% decrease
|
-
|
-
|
-
|
1.87
|
1.12–3.11
|
0.020
|
- APACHE, Acute Physiology and Chronic Health Evaluation. All patients with baseline protein C values from the PROWESS trial (n = 1574) were included in analyses. Risk factors used were previously found to be significant predictors of outcome in analyses of data from PROWESS [15]. aBased on multivariable logistic regression; values >1 indicate increased risk, values <1 indicate lower risk. bPer 5-point increase in baseline score. cPer 5-year increase in age. dPer 10 times increase in baseline IL-6. ePatient was considered dependent if they were dependent in one or more activities on the Activities of Daily Living scale [16].
