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Table 3 Adverse event profile

From: Sedation in the intensive care unit with remifentanil/propofol versus midazolam/fentanyl: a randomised, open-label, pharmacoeconomic trial

  Remifentanil/propofol (n = 40) Midazolam/fentanyl (n = 39) P valuea
Any adverse event 23 24 NS
Any drug-related adverse event 9 2 <0.05
Shivering 8 2 NS
Pain 2 0 NS
Any serious adverse event 4 6 NS
Any drug-related serious adverse event 0 0 NS
Most commonly occurring adverse events (≥ 5% of patients)    
   Shivering 14 6 NS
   Delirium 7 9 NS
   Pain 3 0 NS
   Tachycardia 2 0 NS
   Neuropathy (nerve injury, e.g., by compression) 1 2 NS
   Respiratory insufficiency 0 3 NS
   Hypotension 3 0 NS
   Haemorrhage 2 2 NS
  1. Values are number of patients with event; multiple entries per patient possible.
  2. aFisher's exact test, two tails, significance level 0.05. NS, not significant.