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Table 2 Regional metabolic and oxygen-derived variables in both groups

From: Small volume of hypertonic saline as the initial fluid replacement in experimental hypodynamic sepsis

 

Bacterial infusion

Fluid resuscitation

 

Follow up

 

T0

T30

T60

T90

T120

T150

T180

T210

mDO2 (ml/minute)

        

   LR

103 ± 11

42 ± 4a

83 ± 10

86 ± 12

57 ± 8a

50 ± 6a

43 ± 6a

38 ± 5a

   HS

86 ± 3

50 ± 3a

85 ± 13

69 ± 10

62 ± 9a

60 ± 9a

63 ± 9a

60 ± 8a

mVO2 (ml/minute)

        

   LR

15.0 ± 2.3

11.3 ± 1.9

20.4 ± 2.5

19.7 ± 2.6

13.3 ± 2.7

15.9 ± 2.1

15.3 ± 2.1

10.5 ± 1.5

   HS

14.8 ± 2.4

11.6 ± 1.5

13.1 ± 1.7

10.9 ± 1.6

11.5 ± 1.4

11.2 ± 1.2

12.6 ± 1.76

12.1 ± 2.1

mO2ER (%)

        

   LR

11.2 ± 2.5

25.3 ± 5.1

22.8 ± 2.4a

24.7 ± 3.4a

32.64 ± 6.0a

38.0 ± 5.8a,b

39.9 ± 5.3a,b

36.5 ± 5.4a,b

   HS

13.2 ± 1.7

22.8 ± 3.4a

18.8 ± 3.4

17.7 ± 2.7

20.3 ± 2.3a

19.8 ± 2.0

21.9 ± 2.2

18.5 ± 1.9

PgCO2 (mmHg)

        

   LR

42.1 ± 1.7

51.4 ± 3.8a

60.2 ± 5.3a

72.2 ± 8.1a

75.2 ± 7.3a

77.0 ± 1.8a

84.8 ± 7.1a

89.7 ± 7.5a

   HS

39.8 ± 1.6

45.1 ± 2.0a

53.5 ± 3.2a

56.0 ± 3.3a

62.8 ± 2.9a

68.8 ± 3.1a

75.5 ± 4.0a

80.6 ± 4.1a

PL (mmol/l)

        

   LR

0.97 ± 0.3

1.73 ± 0.4a

2.48 ± 0.4a

3.70 ± 0.5a

3.65 ± 0.4a

4.14 ± 0.6a

5.21 ± 1.0a

4.70 ± 0.9a

   HS

1.42 ± 0.2

1.98 ± 0.3a

2.81 ± 0.31a

4.24 ± 0.2a

4.88 ± 0.3a

4.52 ± 0.2a

4.61 ± 0.2a

4.52 ± 0.2a

  1. Bacterial infusion: intravenous infusion of 1.2 × 1010 cfu/kg of live Escherichia coli in 30 minutes in both groups. Fluid resuscitation: LR group received lactated Ringer's solution 32 ml/kg over 30 minutes, n = 7; HS group received 7.5% hypertonic saline solution 4 ml/kg over 5 minutes, n = 8. Follow up: 120 minutes without additional interventions. mDO2, mesenteric oxygen delivery; mVO2, mesenteric oxygen consumption; mO2ER, mesenteric oxygen extraction rate; PgCO2, gastric mucosal pCO2; PL, portal vein lactate. Data are expressed as mean ± standard error. ap < 0.05 versus T0, both groups; bp < 0.05, LR versus HS.