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  • Meeting abstract
  • Open Access

Cardiac surgery induces increased production of interleukin-10 and lactoferrin

  • 1,
  • 2,
  • 1, 2,
  • 1,
  • 2 and
  • 1
Critical Care20003 (Suppl 1) :P113

https://doi.org/10.1186/cc487

  • Published:

Keywords

  • Endothelial Cell
  • Immune Response
  • Clinical Study
  • Plasma Level
  • Cardiac Operation

Objective of the study

The interaction of blood with nonphysiologic surfaces during cardiac operations with extracorporeal circulation activates leukocytes and endothelial cells with the release of various systemic inflammatory mediators. The balance of pro- and anti-inflammatory factors is important in the limitation of SIRS development. In this study we turned out our attention to interleukin-10 and lactoferrin (LF) which role in the regulation of immune response has already been established.

Study design

Prospective, clinical study approved by the local Ethical Committee.

Patients

We assessed 24 patients subjected to coronary artery bypass graft (CABG) operations. ECC time was 90–115 min and AC time was 70-80 min.

Methods

IL-10 and LF level was measured before the operation after induction of anaesthesia (1), during surgery (2) and then 24 (3) and 48 (4) h after the end of ECC. All measurements were done in duplicate using ELISA techniques.

Results

We observed low plasma level of both IL-10 and LF before the operation and significantly increased during the operations. Postoperatively the concentration of both mediators decreased to the baseline level.

Conclusion

Extracorporeal circulation is associated with the excessive release of IL-10 and lactoferrin and the kinetic of production of these both factors is very similar. This may suggest that they participate in the limitation of the inflammatory process during ECC.

Table

Time of sampling

IL-10 (pg/ml)

Lactoferrin (ng/ml)

Before the operation

54.2 ± 58.6

  297.3 ± 296.7

During ECC

97.3 ± 84.7

1228.8 ± 842.5

24 h after operation

60.0 ± 31.0

  315.5 ± 338.8

48 h after operation

39.8 ± 23.6

  259.2 ± 213.8

Authors’ Affiliations

(1)
Department of Anaesthesiology and Intensive Therapy, Wroclaw University of Medicine, Chalubinskiego la, 50-368 Wroclaw, Poland
(2)
Institute of Immunology and Experimental Therapy, Weigla 12, 53-114 Wroclaw, Poland

Copyright

© Current Science Ltd 1999

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