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Cardiac surgery induces increased production of interleukin-10 and lactoferrin

Objective of the study

The interaction of blood with nonphysiologic surfaces during cardiac operations with extracorporeal circulation activates leukocytes and endothelial cells with the release of various systemic inflammatory mediators. The balance of pro- and anti-inflammatory factors is important in the limitation of SIRS development. In this study we turned out our attention to interleukin-10 and lactoferrin (LF) which role in the regulation of immune response has already been established.

Study design

Prospective, clinical study approved by the local Ethical Committee.


We assessed 24 patients subjected to coronary artery bypass graft (CABG) operations. ECC time was 90–115 min and AC time was 70-80 min.


IL-10 and LF level was measured before the operation after induction of anaesthesia (1), during surgery (2) and then 24 (3) and 48 (4) h after the end of ECC. All measurements were done in duplicate using ELISA techniques.


We observed low plasma level of both IL-10 and LF before the operation and significantly increased during the operations. Postoperatively the concentration of both mediators decreased to the baseline level.


Extracorporeal circulation is associated with the excessive release of IL-10 and lactoferrin and the kinetic of production of these both factors is very similar. This may suggest that they participate in the limitation of the inflammatory process during ECC.


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Adamik, B., Kübler-Kielb, J., Wlaszczyk, A. et al. Cardiac surgery induces increased production of interleukin-10 and lactoferrin. Crit Care 3 (Suppl 1), P113 (2000).

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