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Table 7 Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio and negative likelihood ratio of inflammatory markers in diagnosing sepsis

From: Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study

Variable Cut-off level Sensitivity (%) Specificity (%) Positive predictive value (%) Negative predictive value (%) Positive likelihood ratio Negative likelihood ratio
Procalcitonin 0.087 ng/ml 79.7 42.1 84.3 34.8 1.4 0.48
  0.1 ng/ml 75.7 52.6 86.2 35.7 1.6 0.46
  0.25 ng/ml 55.0 89.5 95.4 34.0 5.2 0.5
  0.5 ng/ml 45.9 89.5 94.4 29.8 4.4 0.6
Lipopolysaccharide-binding protein 20 μg/ml 81.0 68.4 90.9 48.2 2.6 0.28
  40 μg/ml 41.9 100.0 100.0 30.7   0.58
C-reactive protein 38 mg/l 79.7 57.9 88.1 42.3 1.9 0.35
  50 mg/l 71.6 63.2 88.3 36.4 1.9 0.45
  100 mg/l 63.5 94.7 97.9 40.0 11.9 0.39
IL-6 25 pg/ml 81.1 78.9 93.8 51.7 3.8 0.24
  50 pg/ml 70.3 89.5 96.3 43.6 6.7 0.33