Table 7 Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio and negative likelihood ratio of inflammatory markers in diagnosing sepsis
Variable | Cut-off level | Sensitivity (%) | Specificity (%) | Positive predictive value (%) | Negative predictive value (%) | Positive likelihood ratio | Negative likelihood ratio |
|---|---|---|---|---|---|---|---|
Procalcitonin | 0.087 ng/ml | 79.7 | 42.1 | 84.3 | 34.8 | 1.4 | 0.48 |
0.1 ng/ml | 75.7 | 52.6 | 86.2 | 35.7 | 1.6 | 0.46 | |
0.25 ng/ml | 55.0 | 89.5 | 95.4 | 34.0 | 5.2 | 0.5 | |
0.5 ng/ml | 45.9 | 89.5 | 94.4 | 29.8 | 4.4 | 0.6 | |
Lipopolysaccharide-binding protein | 20 μg/ml | 81.0 | 68.4 | 90.9 | 48.2 | 2.6 | 0.28 |
40 μg/ml | 41.9 | 100.0 | 100.0 | 30.7 | 0.58 | ||
C-reactive protein | 38 mg/l | 79.7 | 57.9 | 88.1 | 42.3 | 1.9 | 0.35 |
50 mg/l | 71.6 | 63.2 | 88.3 | 36.4 | 1.9 | 0.45 | |
100 mg/l | 63.5 | 94.7 | 97.9 | 40.0 | 11.9 | 0.39 | |
IL-6 | 25 pg/ml | 81.1 | 78.9 | 93.8 | 51.7 | 3.8 | 0.24 |
50 pg/ml | 70.3 | 89.5 | 96.3 | 43.6 | 6.7 | 0.33 |