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Impact of cardiopulmonary-bypass assisted surgery on markers of monocyte function

An APACHE-II-score ≥ 24 on the 1 po day is a prospectively validated parameter to identify cardiac surgery patients with an escalating `post pump' systemic inflammatory response syndrome at high risk of multiple organ dysfunction syndrome. We investigated the impact of cardiopulmonary bypass-assisted cardiac surgery on monocyte markers in a prospectively conducted study for up to 5 days (group 1: APACHE II ≥ 24, group 2: APACHE II <24), compared to septic non-surgical patients (Elebute sepsis score ≥ 12, APACHE II score ≥ 24).


HLA-DR: significant fall from day 0 to day 1 (P < 0.05; generalised linear model), but no significant difference between groups 1 and 2; CD 86: no significant differences.

Mean channel fluorescence (FACS®) ± SD, corrected by isotype control:


The expression of HLA-DR and CD86 on monocytes does not allow for an early risk stratification after cardiac surgery.

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Neuhaus, K., Müller-Werdan, U., Riemann, D. et al. Impact of cardiopulmonary-bypass assisted surgery on markers of monocyte function. Crit Care 3 (Suppl 1), P112 (2000).

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  • Risk Stratification
  • Organ Dysfunction
  • Systemic Inflammatory Response Syndrome
  • Isotype Control
  • Multiple Organ Dysfunction Syndrome