Table 2 Surviving Sepsis Campaign: sepsis resuscitation bundle

1

Serum lactate measured

2

Blood cultures obtained before antibiotic administration

3

From the time of presentation, broad-spectrum antibiotics administered within 3 hours for ED admissions and 1 hour for non-ED intensive care unit admissions

4

In the event of hypotension and/or lactate >4 mmol/l (36 mg/dl):

   Deliver an initial minimum of 20 ml/kg of crystalloid (or colloid equivalent)

   Apply vasopressors for hypotension not responding to initial fluid resuscitation to maintain mean arterial pressure >65 mmHg

5

In the event of persistent hypotension despite fluid resuscitation (septic shock) and/or lactate >4 mmol/l (36 mg/dl):

   Achieve central venous pressure >8 mmHg

   Achieve central venous oxygen saturation >70%