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Addition of propofol, midazolam, or haloperidol to sufentanil for intravenous sedation in the ICU using the bispectral index
Critical Care volume 10, Article number: P435 (2006)
Inadequate sedative techniques may adversely affect morbidity and mortality in the ICU, and the search for the ideal sedative agent continues. Combinations of hypnotics and opiates have become commonly used for sedation. In our study, we aimed to assess whether the addition of propofol, midazolam, or halo-peridol infusion decreased or not the sufentanil requirements using the bispectral index (BIS).
Materials and methods
The study was planned in 60 ICU patients. All patients received 0.5 mg/kg sufentanil i.v. bolus. Immediately after, Group S received 0.25 mg/kg sufentanil infusion, Group SP received sufentanil infusion + propofol 25 mg/kg/min infusion, Group SM received sufentanil infusion + midazolam 0.04 mg/kg/hour infusion, and Group SH received sufentanil infusion + haloperidol 3 mg/kg/hour infusion for 6 hours. Average BIS values were kept in the range of 61–80 by decreasing or increasing sufentanil levels in all groups, and hourly sufentanil consumption was determined. Hemodynamic, biochemical parameters, and arterial blood gases were determined at baseline, and were repeated in study hours.
There was no significant difference in hemodynamic and biochemical parameters and arterial blood gases among the groups. Propofol, midazolam, and haloperidol infusion, when added to sufentanil infusion, decreased the consumption of sufentanil in all the measured times (P < 0.001).
We aimed to determine the effect of propofol, midazolam, or haloperidol infusion when added to sufentanil infusion in a short period of time, and found that propofol, midazolam, or haloperidol infusion decreased sufentanil requirements in ICU patients.
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Tukenmez, B., Memis, D. & Pamukcu, Z. Addition of propofol, midazolam, or haloperidol to sufentanil for intravenous sedation in the ICU using the bispectral index. Crit Care 10, P435 (2006). https://doi.org/10.1186/cc4782
- Biochemical Parameter
- Intravenous Sedation